Results 161 to 170 of about 409,457 (308)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Molecular reprogramming in cutaneous melanoma: the central role of G9a and EZH2 methyltransferase inhibitors in tumor plasticity, immune evasion, and therapeutic resistance. [PDF]

Front Pharmacol
Nisimoto MYSM, de Oliveira DA, Bottura HR, Germano Sousa WR, Sividanes GDN, Marques AF, Hunnicutt JMS, Romagnolo AG, Vivi MCF, Gorini BL, Paschoal FM, Neto MS, Jasiulionis MG, Marti LC, de Oliveira Filho RS.   +14 more
europepmc   +1 more source

Non-Lethal Weapons and the Sensory Repression of Dissent in Democracies

This article examines the use of ‘non-lethal’ weapons (NLWs) by liberal democracies to govern dissent in non-war contexts. We argue that NLWs can enable sensorial governance, specifically through sensory repression of dissent.
Kaul, N., Cachelin, S.
core   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

FOXA2 potently represses NF-κB-dependent transcription from viral promoters in liver cells. [PDF]

J Biol Chem
Suleiman T, Walker MD.
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Strategies and applications for alleviating carbon catabolite repression. [PDF]

Synth Syst Biotechnol
Lu M, Ding H, Zhang H, Xu J, Meng R, Li Y, Zhang Z, Zheng P, Zhu Y, Sun J.   +9 more
europepmc   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

A Hox-dependent anchoring mechanism mediates transcriptional repression of autophagy-related genes at the nuclear periphery. [PDF]

Proc Natl Acad Sci U S A
Vanderperre S, Ajuria L, Duffraisse M, Da Silva T, Vonau S, Brocard J, Forcet C, Merabet S.   +7 more
europepmc   +1 more source

Financial liberalization, saving, investment and growth in MENA countries [PDF]

Over the last two decades MENA countries as much of the developing countries have experienced a wave of liberalization of financial sector. The purpose of this paper is three fold: to review the literature on the rationale for financial repression ...
Lahcen ACHY
core