Results 201 to 210 of about 89,603 (266)

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Engineering an Optogenetic pH‐Modulator in Bacteria

Advanced Science, EarlyView.
ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang, Olivia J. Armendarez, Wei‐Ting Chang, Matthew M. Hausladen, Shanna Bonanno, Daniel J. Wilson, Neel S. Joshi, Leila F. Deravi   +7 more
wiley   +1 more source

Financial Repression

, 2015
G. Hulsmann
core  

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To repress or not to repress: This is the guardian's question

Trends in Cell Biology, 2011
p53 is possibly the most central tumor suppressor gene of our cells, integrating stress signals to activate a transcriptional program responsible for maintaining cellular homeostasis. Many of the downstream effects of p53 are a consequence of its activity as a transcription factor, resulting in the induction of multiple target genes.
John L, Rinn, Maite, Huarte
openaire   +2 more sources

Sex and Repression

Science, 1999
In a Perspective, [Kuroda and Kelley][1] discuss the new finding ([ Dawes et al .][2]) that SDC-2, a protein with gene repressor and chromosome-wide repressor activity, can regulate both sexual development and dosage compensation (that is, equal X-linked gene expression in both XX hermaphrodite and XO male nematodes) in C. elegans .
M I, Kuroda, R L, Kelley
openaire   +2 more sources

Repression and Psychopathology

Journal of Projective Techniques, 1959
(1959). Repression and Psychopathology. Journal of Projective Techniques: Vol. 23, No. 4, pp. 412-416.
R H, DANA, K, CHRISTIANSEN
openaire   +2 more sources

ARE THERE PRECURSORS TO REPRESSION?

The Journal of Nervous and Mental Disease, 1977
The author examines the possibility that repression has developed out of phylo- and ontogenetic precursors. The adaptive task of repression is to control instinctual behavior by screening out those stimuli (internal or external) which could trigger unacceptable behavior.
openaire   +2 more sources

Transcriptional repression in eukaryotes: repressors and repression mechanisms

Cellular and Molecular Life Sciences (CMLS), 2003
For many, if not most genes, the initiation of transcription is the principle point at which their expression is regulated. Transcription factors, some of which bind to specific DNA sequences, generally either activate or repress promoter activity and thereby control transcription initiation.
Gaston, K, Jayaraman, P-S
openaire   +2 more sources