Results 121 to 130 of about 297,096 (313)

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Transitional Justice: Key Concepts, Processes and Challenges [PDF]

, 2011
This briefing paper focuses on transitional justice as one of the key steps in peacebuilding that needs to be taken to secure a stable democratic future.
Sandoval, C
core  

Developing Derrida’s psychoanalytic graphology: diametric and concentric spatial movements [PDF]

, 2013
Derrida’s work encompasses dynamic spatial dimensions to understanding as a pervasive theme, including the search for a ‘new psychoanalytic graphology’ in Writing and Difference.
Downes, Paul
core   +1 more source

PWOs repress gene transcription by regulating chromatin structures in Arabidopsis

Nucleic Acids Research
Abstract PWWP-DOMAIN INTERACTOR OF POLYCOMBS (PWO) family proteins play a vital role in regulating plant development. However, the molecular mechanisms of how PWOs regulate chromatin structure is elusive. Our data show that the PWO1 binding sites are enriched with positive modifications but exclusive with H3K27me3.
Tingting Yang, Dingyue Wang, Lingxiao Luo, Xiaochang Yin, Zhihan Song, Minqi Yang, Yue Zhou   +6 more
openaire   +2 more sources

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Anarquistas de Ayer y de Hoy. De la identitad antifascista en la guerra civil española a la Memoria actual

Diacronie. Studi di Storia Contemporanea, 2011
The article starts from the idea that there is a common aspect between today and yesterday anarchism, which is its direct opposition to the “voluntary servitude” and the claim of freedom against any kind of authority and tyranny. The transmission of this
Carmen González Martínez es profesora de Historia Contemporánea en la Universidad de Murcia (España), ha dictado conferencias en Inglaterra, Francia, México, Chile, Cuba y Brasil. Su investigación responde a la doble perspectiva de la Historia Regional y la Historia Comparada. Este artículo profundiza en la línea de investigación abordada en Guerra Civil en Murcia. Un análisis sobre el Poder y los comportamientos colectivos (Murcia, 1999) y «El Frente Popular en España: de estrategia interclasista a su superación por la táctica de ‘tomar el cielo por asalto’» (Revista de Historia Social y de las Mentalidades, vol. 14, 2010, Chile). Ha sido coeditora del Dossier: Procesos de Construcción de la democracia en España y Chile (Ayer, nº 79, 3, 2010).
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