Results 81 to 90 of about 92,184 (310)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Genome-Wide Identification and Characterization of the 4-Coumarate: CoA Ligase (4CL) Gene Family in Miscanthus lutarioriparius: Transcriptional Response to Cadmium Stress

Agronomy
Miscanthus lutarioriparius exhibits strong potential for cadmium (Cd) accumulation, making it a promising candidate for the phytoremediation of Cd-contaminated soils.
Xiaowei Huang, Xuanwei Zhou, Yiyang Peng, Tongcheng Fu, Meng Li, Zili Yi, Shuai Xue   +6 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

Evolution der translationalen Repression von caudal in höheren Insekten [PDF]

, 2011
Der anterior lokalisierte Entwicklungsfaktor bicoid (bcd) steuert the translationale Repression von caudal (cad) in Drosophila Embryos. Das bcd Gen kommt im Gegensatz zu cad nur in einer abgeleiteten
Rödel, Claudia Jasmin
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Repression and Protest. Structural Models and Strategic Interactions

, 2011
Les printemps arabes ont remis sur le devant de la scène une vieille interrogation des théories de l’action collective : la répression stimule-t-elle ou annihile-t-elle la mobilisation ? Cet article se propose de dresser un bilan des savoirs sur la question et, au-delà, de proposer quelques pistes de recherche afin de dépasser certaines apories ...
Combes, Hélène, Fillieule, Olivier
openaire   +4 more sources

Controlling Women and Men Through Gendered Repression

Dramatic crackdowns on women’s rights in states like Iran and Afghanistan have drawn international condemnation and renewed calls to recognize ‘Gender Apartheid’ as a crime under international law.
Devereaux, Tessa, Hill, Daniel W.
core   +1 more source

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

, 2016
The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis.
Roos, Anette K.,, Udo C T Oppermann, Opher Gileadi (386939), Roos, Anette K., Gileadi, Opher, Udo C. T. Oppermann (2513599), Cooper, Christopher D O, Cho, Hearn J.,, Gileadi, Opher,, Gileadi, O, Opher Gileadi, Oppermann, UC, Aitkenhead, H, Roman Osman (28623), Cho, Hearn J., Roos, AK, Anette K. Roos (2513605), Cooper, CD, Christopher D. O. Cooper (208678), Christopher D O Cooper, Hearn J Cho, Aitkenhead, Hazel, Oppermann, Udo C T, Cooper, Christopher D. O.,, Joseph A. Newman (2513593), Hearn J. Cho (2513602), Anette K Roos, Hazel Aitkenhead, Cho, HJ, Oppermann, Udo C. T.,, Hazel Aitkenhead (2513596), Newman, Joseph A., Newman, Joseph A.,, Aitkenhead, Hazel,, Osman, Roman, Oppermann, Udo C. T., Roman Osman, Osman, Roman,, Cooper, Christopher D. O., Newman, JA, Joseph A Newman, Osman, R, Cooper, Christopher D.O., Oppermann, Udo C.T.   +43 more
core   +1 more source

Insight into microRNA regulation by analyzing the characteristics of their targets in humans

BMC Genomics, 2009
Background microRNAs (miRNAs) are believed to regulate their targets through posttranscriptional gene regulation and have the potential to silence gene expression via multiple mechanisms.
Hu Zihua
doaj   +1 more source