Results 61 to 70 of about 92,184 (310)

Repression by Proxy

, 2015
Why do regimes delegate authority over a territory to nonstate militias, in effect voluntarily sacrificing their monopoly over the use of violence? This article argues that two factors increase the probability of states delegating control to a proxy ...
Kristine Eck, Eck, Kristine,
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Structural basis for the Nanos-mediated recruitment of the CCR4–NOT complex and translational repression [PDF]

Genes & Development, 2014
The RNA-binding proteins of the Nanos family play an essential role in germ cell development and survival in a wide range of metazoan species. They function by suppressing the expression of target mRNAs through the recruitment of effector complexes, which include the CCR4–NOT deadenylase complex.
D. Bhandari, T. Raisch, O. Weichenrieder, S. Jonas, E. Izaurralde   +4 more
openaire   +3 more sources

Childhood Trauma, Repression, and Feminist Reimagining Behind Locked Doors: The Witch, a film by Erman Bostan

CINEJ Cinema Journal
The Witch (Tr: Cadı, Erman Bostan, 2024), loosely adapted from Hüseyin Rahmi Gürpınar’s 1912 novel, reimagines the witch not as a supernatural being but as a cultural construct shaped by superstition, trauma, and gendered subjectivity. This study argues
İrem Çoban
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi. [PDF]

PLoS ONE, 2011
RNA interference can be mediated by fully complementary siRNA or partially complementary miRNA. siRNAs are widely used to suppress viral replication and the fully complementary siRNA bound Ago-2 in the RISC is known to degrade the target RNA.
Shuiping Chen, Harendra S Chahar, Sojan Abraham, Haoquan Wu, Theodore C Pierson, Xiaozhong A Wang, N Manjunath   +6 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling [PDF]

Nature, 2015
The plant hormone jasmonate plays crucial roles in regulating plant responses to herbivorous insects and microbial pathogens and is an important regulator of plant growth and development. Key mediators of jasmonate signalling include MYC transcription factors, which are repressed by jasmonate ZIM-domain (JAZ) transcriptional repressors in the resting ...
Zhang, Feng, Yao, Jian, Ke, Jiyuan, Zhang, Li, Lam, Vinh Q, Xin, Xiu-Fang, Zhou, X Edward, Chen, Jian, Brunzelle, Joseph, Griffin, Patrick R, Zhou, Mingguo, Xu, H Eric, Melcher, Karsten, He, Sheng Yang   +13 more
openaire   +2 more sources

Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae [PDF]

, 2009
Background In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect.
Esther R Loney, Pryde, Fiona E., Louis Edward J, Pryde, FE, F. E. Pryde (7675940), Mellor, J., P. W. Inglis (7675937), Nicholas A Kent, J. Mellor (27566), Pryde Fiona E, Mellor Jane, Sharp Sarah, Kent Nicholas A, Loney, E. R., Sharp, Sarah, Sharp, S., Edward John Louis (7604981), Sharp, S, Kent, NA, S. Sharp (7639394), Inglis, Peter W., Louis, Edward J., Inglis, P. W., Inglis, PW, N. A. Kent (7675943), Peter W Inglis, Loney, Esther R., Kent, Nicholas A., Jane Mellor, Mellor, J, Edward J Louis, Pryde, F. E., Louis, E. J., Loney Esther R, Inglis Peter W, Loney, ER, Louis, EJ, E. R. Loney (7675934), Mellor, Jane, Fiona E Pryde, Sarah Sharp   +40 more
core   +1 more source

Del odio de la casa caribe a la tragedia de la casa andaluza: La casa grande de Álvaro Cepeda Samudio y La casa de Bernarda Alba de Federico García Lorca

Estudios de Literatura Colombiana, 2013
Se analiza la relación entre La casa de Bernarda Alba de Federico García Lorca y La Casa Grande de Álvaro Cepeda Samudio, centrándose en el contraste entre rebelión y represión que caracteriza a ambas obras, con particular atención a la importancia de ...
Elena Bastasi
doaj   +1 more source