Results 41 to 50 of about 92,184 (310)

Mechanisms of peptide sex pheromone regulation of conjugation in Enterococcus faecalis

MicrobiologyOpen, 2017
In many gram positive bacteria, horizontal transfer and virulence are regulated by peptide‐mediated cell‐cell signaling. The heptapeptide cCF10 (C) activates conjugative transfer of the Enterococcus faecalis plasmid pCF10, whereas the iCF10 (I) peptide ...
Yuqing Chen, Arpan Bandyopadhyay, Briana K. Kozlowicz, Heather A. H. Haemig, Albert Tai, Wei‐Shou Hu, Gary M. Dunny   +6 more
doaj   +1 more source

Cercetări arheologice în fosta colonie de muncă forţată din perioada comunistă de la Peninsula, canalul Dunăre – Marea Neagră

Materiale și Cercetări Arheologice, 2023
Despite the fact that Peninsula occupies an important place in the memorial literature and historical works regarding the political repression in communist Romania, the materiality of this forced labour colony on the trail of the Danube ‒ Black Sea Canal
Dragoman, A., Oanță-Marghitu, S., Nicolae, C., Florea, M.   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Activation and repression of transcription initiation by a distant DNA structural transition [PDF]

Molecular Microbiology, 2001
Negative superhelical tension can drive local transitions to alternative DNA structures. Long regions of DNA may contain several sites that are susceptible to forming alternative structures. Their relative propensities to undergo transition are ordered according to the energies required for their formation.
S D, Sheridan, M L, Opel, G W, Hatfield
openaire   +2 more sources

NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE

Инфекция и иммунитет, 2014
. Streptococcus agalactiae can cause variety of diseases of newborns and adults. For successful colonization of different human tissues and organs as well as for suppression of the host immune system S.
A. S. Rozhdestvenskaya, I. Santos-Sanches, A. V. Dmitriev   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Unraveling Mechanisms of Transcriptional Repression: Novel Insights from Brinker [PDF]

, 2013
Transcriptional repressors bind cis-regulatory elements of target genes in a sequence specific manner. To antagonize transcription, repressors primarily function by recruiting accessory proteins, co-repressors, which in turn largely function by modifying
Upadhyai, Priyanka
core  

Structure of frequency-interacting RNA helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance. [PDF]

PLoS ONE, 2018
The FRH (frequency-interacting RNA helicase) protein is the Neurospora crassa homolog of yeast Mtr4, an essential RNA helicase that plays a central role in RNA metabolism as an activator of the nuclear RNA exosome. FRH is also a required component of the
Yalemi Morales, Keith J Olsen, Jacqueline M Bulcher, Sean J Johnson   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Decoding Hairpin Structure Stability in Lin28-mediated Repression

Biochemistry
The Lin28 protein is well known for its role in inhibiting the biogenesis of microRNAs (miRNAs) that belong to the let-7 family. The Lin28 and let-7 axes are associated with several types of cancers. It is imperative to understand the underlying mechanism to treat these cancers in a more efficient way.
Qiang Zhu, Limu Hu, Chang Cui, Min Zang, Hao Dong, Jing Ma   +5 more
openaire   +2 more sources