Results 41 to 50 of about 93,471 (266)

Decoding Hairpin Structure Stability in Lin28-mediated Repression

Biochemistry
Lin28 protein is well-known for its role in inhibiting biogenesis of micro-RNAs (miRNAs) that belong to the let-7 family. The Lin28 and let-7 axis is associated with several types of cancer. It is imperative to understand the underlying mechanism to treat these cancer in a more efficient way.
Qiang Zhu, Limu Hu, Chang Cui, Min Zang, Hao Dong, Jing Ma   +5 more
openaire   +2 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Cercetări arheologice în fosta colonie de muncă forţată din perioada comunistă de la Peninsula, canalul Dunăre – Marea Neagră

Materiale și Cercetări Arheologice, 2023
Despite the fact that Peninsula occupies an important place in the memorial literature and historical works regarding the political repression in communist Romania, the materiality of this forced labour colony on the trail of the Danube ‒ Black Sea Canal
Dragoman, A., Oanță-Marghitu, S., Nicolae, C., Florea, M.   +3 more
doaj   +1 more source

Translational repression by the cis‐acting element of structure‐anchored repression (CAESAR) of human ctgf/ccn2 mRNA [PDF]

FEBS Letters, 2005
The cis‐acting element of structure‐anchored repression (CAESAR) is a post‐transcriptional regulatory element of gene expression, which is located in the 3′‐untranslated region (UTR) of the human ccn2 gene (ctgf/ccn2). In this report, the repression mechanism of CAESAR, as well as the structural requirement, was investigated.
Kubota, Satoshi, Mukudai, Yoshiki, Moritani, Norifumi H., Nakao, Kyouji, Kawata, Kazumi, MasaharuTakigawa,   +5 more
openaire   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Repression in Disguise: Effects of Covert Repression on the Erosion of Social Movements in Post-Indignados Madrid

Partecipazione e Conflitto
The growing securitization and criminalization of social movements in Europe raise concerns about the erosion of public freedoms. Yet scholarship often emphasizes overt repression, neglecting the effects of more covert strategies.
Mert Arslanalp, Gomer Betancor Nuez
doaj   +1 more source

NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE

Инфекция и иммунитет, 2014
. Streptococcus agalactiae can cause variety of diseases of newborns and adults. For successful colonization of different human tissues and organs as well as for suppression of the host immune system S.
A. S. Rozhdestvenskaya, I. Santos-Sanches, A. V. Dmitriev   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Structure of frequency-interacting RNA helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance. [PDF]

PLoS ONE, 2018
The FRH (frequency-interacting RNA helicase) protein is the Neurospora crassa homolog of yeast Mtr4, an essential RNA helicase that plays a central role in RNA metabolism as an activator of the nuclear RNA exosome. FRH is also a required component of the
Yalemi Morales, Keith J Olsen, Jacqueline M Bulcher, Sean J Johnson   +3 more
doaj   +1 more source

Structural basis for the Nanos-mediated recruitment of the CCR4–NOT complex and translational repression [PDF]

Genes & Development, 2014
The RNA-binding proteins of the Nanos family play an essential role in germ cell development and survival in a wide range of metazoan species. They function by suppressing the expression of target mRNAs through the recruitment of effector complexes, which include the CCR4–NOT deadenylase complex.
D. Bhandari, T. Raisch, O. Weichenrieder, S. Jonas, E. Izaurralde   +4 more
openaire   +3 more sources