Results 31 to 40 of about 93,471 (266)
eLife, 2017 Ring-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a central pore. This activity is potentially harmful requiring mechanisms for tight repression and substrate-specific activation.
Marta Carroni +10 more
doaj +1 more source
PLoS ONE, 2016 Heterochromatinisation of pericentromeres, which in mice consist of arrays of major satellite repeats, are important for centromere formation and maintenance of genome stability.
Theona Natisvili +6 more
doaj +1 more source
Activation and repression of transcription initiation by a distant DNA structural transition [PDF]
Molecular Microbiology, 2001 Negative superhelical tension can drive local transitions to alternative DNA structures. Long regions of DNA may contain several sites that are susceptible to forming alternative structures. Their relative propensities to undergo transition are ordered according to the energies required for their formation.
S D, Sheridan, M L, Opel, G W, Hatfield
openaire +2 more sources
Estrogen represses gene expression through reconfiguring chromatin structures [PDF]
Nucleic Acids Research, 2013 Estrogen regulates over a thousand genes, with an equal number of them being induced or repressed. The distinct mechanisms underlying these dual transcriptional effects remain largely unknown. We derived comprehensive views of the transcription machineries assembled at estrogen-responsive genes through integrating multiple types of genomic data. In the
Osmanbeyoglu, Hatice Ulku +6 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Germany Democratic Republic and Polish National Republic political polices
Genocidas ir Rezistencija, 2006 The Soviet regime needed to establish security structures in the satellite states. Due to the weak satellite communist parties (further weakened by Stalin’s repression), the Soviet regime had no confidence in its allies.
Kazimierz Woycicki
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Cells, 2020 Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov +7 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Mechanisms of peptide sex pheromone regulation of conjugation in Enterococcus faecalis
MicrobiologyOpen, 2017 In many gram positive bacteria, horizontal transfer and virulence are regulated by peptide‐mediated cell‐cell signaling. The heptapeptide cCF10 (C) activates conjugative transfer of the Enterococcus faecalis plasmid pCF10, whereas the iCF10 (I) peptide ...
Yuqing Chen +6 more
doaj +1 more source
Detection and functional characterization of a 215 amino acid N-terminal extension in the Xanthomonas type III effector XopD. [PDF]
PLoS ONE, 2010 During evolution, pathogens have developed a variety of strategies to suppress plant-triggered immunity and promote successful infection. In Gram-negative phytopathogenic bacteria, the so-called type III protein secretion system works as a molecular ...
Joanne Canonne +7 more
doaj +1 more source