Results 11 to 20 of about 92,184 (310)

The Changing Dynamics of Oppression: Polish Repression Apparatus in the Years 1944–1956 [PDF]

Časopis Ksio
This study examines the Polish repression apparatus from 1944 to 1956, tracing its development within the framework of Soviet-controlled governance.
Adam Oziemski
doaj   +2 more sources

Structural insight into glucose repression of the mannitol operon [PDF]

Scientific Reports, 2019
AbstractCarbon catabolite repression is a regulatory mechanism to ensure sequential utilization of carbohydrates and is usually accomplished by repression of genes for the transport and metabolism of less preferred carbon compounds by a more preferred one.
Mangyu Choe, Huitae Min, Young-Ha Park, Yeon-Ran Kim, Jae-Sung Woo, Yeong-Jae Seok   +5 more
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Structure, mechanism, and regulation of polycomb-repressive complex 2 [PDF]

Journal of Biological Chemistry, 2018
Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3, a modification associated with epigenetic gene silencing. This complex plays a fundamental role in regulating cellular differentiation and development, and PRC2 overexpression and mutations have been implicated in numerous cancers.
Lindsay E, Moritz, Raymond C, Trievel
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Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction

Structure, 2023
Abstract Heterochromatin protein 1 (HP1) plays a central role in establishing and maintaining constitutive heterochromatin. However, the mechanisms underlying HP1-nucleosome interactions and their contributions to heterochromatin functions remain elusive.
Vladyslava Sokolova, Jacob Miratsky, Vladimir Svetlov, Michael Brenowitz, John Vant, Tyler S. Lewis, Kelly Dryden, Gahyun Lee, Shayan Sarkar, Evgeny Nudler, Abhishek Singharoy, Dongyan Tan   +11 more
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Structure theorems and the dynamics of nitrogen catabolite repression in yeast [PDF]

Proceedings of the National Academy of Sciences, 2005
By using current biological understanding, a conceptually simple, but mathematically complex, model is proposed for the dynamics of the gene circuit responsible for regulating nitrogen catabolite repression (NCR) in yeast. A variety of mathematical “structure” theorems are described that allow one to determine the asymptotic dynamics of complicated ...
Erik M, Boczko, Terrance G, Cooper, Tomas, Gedeon, Konstantin, Mischaikow, Deborah G, Murdock, Siddharth, Pratap, K Sam, Wells   +6 more
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The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain [PDF]

, 2014
BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma.
Simon D. Wagner (530388), Jamieson, Andrew G, Louise Fairall, Simon D Wagner, Wagner, Simon D, Jamieson Andrew G., Schwabe John W. R., Ko Ferrigno Paul, John W. R. Schwabe (7604093), Paul Ko Ferrigno (41085), Goult, Benjamin T., Wagner, SD, Benjamin T Goult, Evans, SE, Ford, Robert, Sian E Evans, Schwabe, JWR, Andrew G Jamieson, Fairall, Louise, Andrew G. Jamieson (530386), Wagner, Simon D., Benjamin T. Goult (173495), Sian E. Evans (7622282), Ko Ferrigno, Paul, Evans, Sian E, Robert Ford (89276), Ford Robert, Schwabe, John W R, Goult Benjamin T., P. Ko Ferrigno (7674905), Evans Sian E., Fairall, L, Fairall Louise, Schwabe, John W.R., Simon D. Wagner (7633943), John W R Schwabe, Evans, Sian E., Goult, Benjamin T, Goult, BT, Robert Ford, Jamieson, Andrew G., Louise Fairall (530385), Ko Ferrigno, P, Ford, R, John W. R. Schwabe (530387), Jamieson, AG, Wagner Simon D., Sian E. Evans (530384), Paul Ko Ferrigno, R. Ford (7674908)   +49 more
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Structural Basis for Retinoic X Receptor Repression on the Tetramer [PDF]

Journal of Biological Chemistry, 2011
Retinoic X receptor (RXR) is a master nuclear receptor in the processes of cell development and homeostasis. Unliganded RXR exists in an autorepressed tetramer, and agonists can induce RXR dimerization and coactivator recruitment for activation. However, the molecular mechanisms involving the corepressor recruitment and antagonist-mediated repression ...
Haitao, Zhang, Lili, Chen, Jing, Chen, Hualiang, Jiang, Xu, Shen   +4 more
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RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression [PDF]

Molecular and Cellular Biology, 2002
RGS12TS-S, an 1,157-amino-acid RGS protein (regulator of G protein signaling), is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. We now report that RGS12TS-S is a nuclear matrix protein and identify structural determinants that target this protein to the ...
Tapan K, Chatterjee, Rory A, Fisher
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Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states. [PDF]

, 2012
Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast.
Ragna Sack, Tsai-Pflugfelder Monika, Gasser, Susan M, Ferreira, Helder C., Kueng Stephanie, Oppikofer, Mariano, Roberts, Emma, Sack, Ragna, Roloff, Tim-Christoph, Gasser, Susan M., Mariano Oppikofer, Chinyen Tsai (163222), Tim-Christoph Roloff (163227), Emma Roberts, Tsai-Pflugfelder, Monika, Helder C. Ferreira (163213), Tsai Chinyen, Ferreira Helder C., Helder C Ferreira, Oppikofer Mariano, Mariano Oppikofer (163208), Kueng, Stephanie, Roloff Tim-Christoph, Ferreira, Helder C, Roberts Emma, Tsai, Chinyen, Stephanie Kueng, Monika Tsai-Pflugfelder, Stephanie Kueng (163200), Susan M Gasser, Ragna Sack (163231), Emma Roberts (163217), Susan M. Gasser (163235), Tim-Christoph Roloff, Monika Tsai-Pflugfelder (163204), Gasser Susan M., Sack Ragna, Chinyen Tsai   +37 more
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Structural basis of RNA polymerase III transcription repression by Maf1 [PDF]

Nature Structural & Molecular Biology, 2019
ABSTRACT Maf1 is a highly conserved central regulator of transcription by RNA polymerase III (Pol III), and Maf1 activity influences a wide range of phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, which establishes how Maf1 achieves transcription repression. In
Vorländer, Matthias K., Baudin, Florence, Moir, Robyn D., Wetzel, René, Hagen, Wim J. H., Willis, Ian M., Müller, Christoph W.   +6 more
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