Results 161 to 170 of about 5,282 (302)

How cells tame noise while maintaining ultrasensitive transcriptional responses. [PDF]

PLoS Comput Biol
Jeong EM, Chung CY, Kim JK.
europepmc   +1 more source

Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients. [PDF]

J Transl Med, 2023
Bayraktar A, Li X, Kim W, Zhang C, Turkez H, Shoaie S, Mardinoglu A.   +6 more
europepmc   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

A tool for modeling gene regulatory networks (GRN_modeler) and its applications to synthetic biology. [PDF]

Mol Syst Biol
Holló G, Park JH, Boni E, Schaerli Y.
europepmc   +1 more source

Catabolite Repression

Cold Spring Harbor Symposia on Quantitative Biology, 1961
openaire   +2 more sources

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Personal Responsibility of Organizers and Participants of Repressions Against Protestant Communities in Ukraine

The article analyzes the personal responsibility of the organizers and participants in the repressions against Protestant communities in Ukraine. The punitive and preventive atheistic campaigns of the communist regime were carried out by specific ...
Fihurnyi, Yurii, Zadorozhnya, Alina, Vysoven, Oksana, Datskiv, Ihor   +3 more
core   +1 more source

Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators. [PDF]

World J Orthop
Paisan M, Papadopoulos KI, Papadopoulou A, Prasongchean W, Wattanaarsakit P.   +4 more
europepmc   +1 more source

Editorial: Migrants' psychosocial health: cultural and religious resources through resilience and coping. [PDF]

Front Sociol, 2023
Cetrez ÖA, Kaynak S.
europepmc   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source