Results 161 to 170 of about 20,465 (309)
Advanced Science, EarlyView.Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang +10 more
wiley +1 more source
MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19. [PDF]
World J Exp MedPapadopoulos KI, Papadopoulou A, Aw TC.
europepmc +1 more source
Advanced Science, EarlyView.Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang +3 more
wiley +1 more source
QOMIC: quantum optimization for motif identification. [PDF]
Bioinform AdvNgo HM, Khatib T, Thai MT, Kahveci T.
europepmc +1 more source
Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Transcription Factor TeMADS6 Coregulates Carotenoid Biosynthesis and Chlorophyll Degradation Resulting in Yellow-Green Petal Color of Marigold (<i>Tagetes erecta</i>). [PDF]
Plants (Basel)Zhang C +8 more
europepmc +1 more source