Results 141 to 150 of about 5,282 (302)
Advanced Science, EarlyView.This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Repressions and War in the Biographical Narratives of Poles Living in Zhytomyr, Kyiv and Podolia Regions [PDF]
, 2010 Artykuł prezentuje miejsce wojny i represji stalinowskich w narracjach biograficznych Polaków z Ukrainy Centralnej. Tekst powstał na podstawie analizy treści 63 wywiadów. Szczegółowej analizie poddane zostały 4 wybrane wywiady, reprezentujące najbardziej
Wylegała, Anna
core
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Soviet Policy towards Buddhist Healthcare System in 1920-1930s: Reforms and Repressions
, 2012 The article analyzes the main stages of interrelations development between the Soviet state and the Buddhist healthcare system (Tibetan medicine) in the 1920-1930s: reforming, confrontation, repressions and elimination.
F L Sinitsyn
core
Robustness and innovation in synthetic genotype networks. [PDF]
Nat Commun, 2023 Santos-Moreno J +4 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
On the Consistency between Gene Expression and the Gene Regulatory Network of Corynebacterium glutamicum. [PDF]
Netw Syst Med, 2021 Parise D +7 more
europepmc +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Russian historiography of Stalin’s repressions (end 1980-h - 2000-h years)
, 2011 В статті аналізується процес вивчення в Росії протягом кінця 1980-х – 2000 – х рр. політичних, соціальних, національних репресій за часів Й.Сталіна. Звертається увага на дискусійний характер сучасної історіографії сталінізму в Росії.
Терлецька, І.
core +1 more source