Results 41 to 50 of about 2,063 (263)
Известия высших учебных заведений. Поволжский регион: Гуманитарные науки, 2020 Background. Failures in socio-economic policy in rural areas in the early thirties forced the party leadership to look for the culprits for disrupting the pace of collectivization.
O. B. Mozokhin
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Studia Koszalińsko-Kołobrzeskie, 2020 The paper focuses on the invalidation of unappeasable judgments delivered against priests in Poland before 1989. The Catholic Church was repressed during the communist period and the priests were persecuted.
Piotr Sobański
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
From ‘the effect of repression’ toward ‘the response to repression’ [PDF]
Current Sociology, 2018 Scholars have long been interested in explaining the effect of state repression on political participation. Recent reviews of research on state repression highlighted contradictory findings about this effect, yet the core question is still debated: what accounts for the variation in the effects of repression?
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Some concers regarding the mass deportations of bessarabians to the USSR between 1940-1941
Astra Salvensis, 2019 In this article, the author presents a general radiography of communist repressions in Soviet Bessarabia between 1940-1941. The author makes some considerations on the nature of these repressions.
Gheorghe Cazacu
doaj
MYC in elongation and repression [PDF]
Nature Reviews Cancer, 2018 Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.
openaire +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source