Results 151 to 160 of about 30,544 (313)

Internet Shutdowns in Africa| Dissent Does Not Die in Darkness: Network Shutdowns and Collective Action in African Countries

International Journal of Communication, 2020
Research on the role of communication technology in repression and collective action focuses largely on social movements in the West or the Arab Spring.
Jan Rydzak, Moses Karanja, Nicholas Opiyo   +2 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Elucidating Nucleic Acid Binding Properties of Polycomb Repressive Complex 2

, 2017
Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase that specifically deposits mono-, di-, and tri-methylation marks onto chromatin. This activity triggers epigenetic silencing, a process critical for cell differentiation and maintenance ...
Paucek, Richard D.
core   +1 more source

Small molecules and heat treatments reverse vernalization via epigenetic modification in Arabidopsis

Communications Biology
Monocarpic plants flower only once and then produce seeds. Many monocarpic plants require a cold treatment known as vernalization before they flower. This requirement delays flowering until the plant senses warm temperatures in the spring.
Nana Otsuka, Ryoya Yamaguchi, Hikaru Sawa, Naoya Kadofusa, Nanako Kato, Yasuyuki Nomura, Nobutoshi Yamaguchi, Atsushi J. Nagano, Ayato Sato, Makoto Shirakawa, Toshiro Ito   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The role of polyhomeotic in polycomb group-mediated regulation of the tumour suppressor P16INK4A

, 2010
The INK4A tumour suppressor gene is negatively regulated by the Polycomb Group (PcG) complexes, which plays an important role in stem cell- and cancer biology.
de Breed, L.A.
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

MODERN GERMAN HISTORIOGRAPHY ON THE MECHANISM FOR CONTROL AND SUPPRESSION OF THE NAZI STATE: GESTAPO AND NAZI CONCENTRATION CAMPS

Вестник Кемеровского государственного университета, 2014
The paper describes the process of the 1990s deployment of German historians’ works to analyse the repressive structures of the Third Reich on the basis of regional and European sources. The major trends and research methodology are analyzed in the paper.
L. N. Korneva
doaj  

A COMMEMORATION OF WOUNDS ENDURED: WRITING AS RESISTANCE IN MARGARET ATWOOD’S THE BLIND ASSASSIN

Filolog
Margaret Atwood’s The Blind Assassin depicts repressive patriarchal practices such as insistence upon the cult of Victorian womanhood and the sacrificial angel trope imposed on women in 1930s and 1940s Canada.
Marija N. Gagić
doaj   +1 more source