Results 11 to 20 of about 30,587 (268)
Structural insight into glucose repression of the mannitol operon [PDF]
Scientific Reports, 2019 AbstractCarbon catabolite repression is a regulatory mechanism to ensure sequential utilization of carbohydrates and is usually accomplished by repression of genes for the transport and metabolism of less preferred carbon compounds by a more preferred one.
Mangyu Choe +5 more
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Structure, mechanism, and regulation of polycomb-repressive complex 2 [PDF]
Journal of Biological Chemistry, 2018 Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3, a modification associated with epigenetic gene silencing. This complex plays a fundamental role in regulating cellular differentiation and development, and PRC2 overexpression and mutations have been implicated in numerous cancers.
Lindsay E, Moritz, Raymond C, Trievel
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Repression of IS200 transposase synthesis by RNA secondary structures [PDF]
Nucleic Acids Research, 1999 The IS 200 transposase, a 16 kDa polypeptide encoded by the single open reading frame (ORF) of the insertion element, has been identified using an expression system based on T7 RNA polymerase. In wild-type IS 200, two sets of internal inverted repeats that generate RNA secondary structures provide two independent mechanisms for repression of ...
Beuzón López, Carmen del Rosario +2 more
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Structure theorems and the dynamics of nitrogen catabolite repression in yeast [PDF]
Proceedings of the National Academy of Sciences, 2005 By using current biological understanding, a conceptually simple, but mathematically complex, model is proposed for the dynamics of the gene circuit responsible for regulating nitrogen catabolite repression (NCR) in yeast. A variety of mathematical “structure” theorems are described that allow one to determine the asymptotic dynamics of complicated ...
Erik M, Boczko +6 more
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Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction
Structure, 2023 Abstract Heterochromatin protein 1 (HP1) plays a central role in establishing and maintaining constitutive heterochromatin. However, the mechanisms underlying HP1-nucleosome interactions and their contributions to heterochromatin functions remain elusive.
Vladyslava Sokolova +11 more
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Structural Basis for Retinoic X Receptor Repression on the Tetramer [PDF]
Journal of Biological Chemistry, 2011 Retinoic X receptor (RXR) is a master nuclear receptor in the processes of cell development and homeostasis. Unliganded RXR exists in an autorepressed tetramer, and agonists can induce RXR dimerization and coactivator recruitment for activation. However, the molecular mechanisms involving the corepressor recruitment and antagonist-mediated repression ...
Haitao, Zhang +4 more
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RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression [PDF]
Molecular and Cellular Biology, 2002 RGS12TS-S, an 1,157-amino-acid RGS protein (regulator of G protein signaling), is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. We now report that RGS12TS-S is a nuclear matrix protein and identify structural determinants that target this protein to the ...
Tapan K, Chatterjee, Rory A, Fisher
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Structural basis of RNA polymerase III transcription repression by Maf1 [PDF]
Nature Structural & Molecular Biology, 2019 ABSTRACT Maf1 is a highly conserved central regulator of transcription by RNA polymerase III (Pol III), and Maf1 activity influences a wide range of phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, which establishes how Maf1 achieves transcription repression. In
Vorländer, Matthias K. +6 more
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Interleukin-6 repression is associated with a distinctive chromatin structure of the gene [PDF]
Nucleic Acids Research, 1999 Expression of the interleukin-6 (IL-6) gene is usually tightly controlled and may be induced in specific tissues only after treatment with appropriate stimuli. The molecular mechanisms responsible for IL-6 gene repression in specific tissues or cell lines remain poorly defined.
ARMENANTE F. +4 more
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Chromatin structure of transcriptionally competent and repressed genes. [PDF]
The EMBO Journal, 1990 We have compared transcriptionally competent and repressed genes with respect to their linker histone content and their ability to fold into higher-order structures. Histones were cross-linked covalently to DNA in chicken erythrocyte and oviduct nuclei by UV irradiation, and the DNA that was immunoprecipitated with anti-H1 and (for erythrocytes) anti ...
R T, Kamakaka, J O, Thomas
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