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Challenges to the Reproducibility of Machine Learning Models in Health Care.

open access: yesJournal of the American Medical Association (JAMA), 2020
Reproducibility has been an important and intensely debated topic in science and medicine for the past few decades.1 As the scientific enterprise has grown in scope and complexity, concerns regarding how well new findings can be reproduced and validated ...
Andrew Beam, A. Manrai, M. Ghassemi
semanticscholar   +1 more source

Registered report: Intestinal inflammation targets cancer-inducing activity of the microbiota

open access: yeseLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012.
Kate Eaton   +2 more
doaj   +1 more source

Reproducibility blues [PDF]

open access: yesThe EMBO Journal, 2015
Research findings advance science only if they are significant, reliable and reproducible. Scientists and journals must publish robust data in a way that renders it optimally reproducible. Reproducibility has to be incentivized and supported by the research infrastructure but without dampening innovation.
openaire   +2 more sources

Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

open access: yeseLife, 2014
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012.
David Blum   +2 more
doaj   +1 more source

Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors

open access: yeseLife, 2014
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012.
Edward Greenfield   +2 more
doaj   +1 more source

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility

open access: yesDisease Models & Mechanisms, 2020
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of inaccessible human cell types, yielding new insights into disease mechanisms especially for neurological disorders.
V. Volpato, C. Webber
semanticscholar   +1 more source

Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

open access: yeseLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Jia Li   +2 more
doaj   +1 more source

Repeatability and Reproducibility of Radiomic Features: A Systematic Review

open access: yesInternational Journal of Radiation Oncology, Biology, Physics, 2018
Purpose: An ever-growing number of predictive models used to inform clinical decision making have included quantitative, computer-extracted imaging biomarkers, or “radiomic features.” Broadly generalizable validity of radiomics-assisted models may be ...
A. Traverso   +3 more
semanticscholar   +1 more source

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation

open access: yesmedRxiv, 2020
Polygenic [risk] scores (PGS) can enhance prediction and understanding of common diseases and traits. However, the reproducibility of PGS and their subsequent applications in biological and clinical research have been hindered by several factors ...
Samuel A. Lambert   +11 more
semanticscholar   +1 more source

Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

open access: yeseLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Brad Evans   +2 more
doaj   +1 more source

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