Results 101 to 110 of about 166,851,649 (309)

Adaptação transcultural, confiabilidade e validade da escala de resiliência

Cadernos de Saúde Pública
Busca-se apresentar os resultados da adaptação transcultural para o português da escala de resilência de Wagnild & Young e da avaliação psicométrica desta.
Renata P. Pesce, Simone G. Assis, Joviana Q. Avanci, Nilton C. Santos, Juaci V. Malaquias, Raquel Carvalhaes   +5 more
doaj  

Reproducibility of AMPLICOR enterovirus PCR test results [PDF]

Journal of Clinical Microbiology, 1997
The reproducibility of AMPLICOR enterovirus PCR test results was determined with clinical samples of cerebrospinal fluid, serum, urine, and throat and rectal swabs. Among 608 samples from which duplicate aliquots were run simultaneously, only seven pairs gave discordant results.
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Grand Rounds: Research Reproducibility - Eric Eide (11-14-2017)

, 2018
Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Reproducibility within Computer Science" Presented by Eric Eide, Research Assistant Professor at the University of Utah School of Computing.
Eric Eide
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Grand Rounds: Research Reproducibility - Robert Ricci (11-07-2017)

, 2018
Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Software for Reproducibility" Presented by Rob Ricci, Research Associate Professor at the University of Utah School of Computing, College of Engineering. GRRR is a
Robert Ricci
core  

Springback effect of ambient-pressure-dried silica aerogels: nanoscopic effects of silylation revealed by in situ synchrotron X-ray scattering. [PDF]

Nanoscale Adv, 2023
Zemke F, Scoppola E, Simon U, Bekheet MF, Wagermaier W, Gurlo A.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Grand Rounds Research Reproducibility - Matt Haber, PhD (03-27-2018)

, 2018
Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Positively Misleading Errors" presented by Matt Haber, PhD, Chair Department Of Philosophy and Center for Quantitative Biology, University of Utah. GRRR is a weekly
Matt Haber, PhD
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source