Results 101 to 110 of about 1,138,858 (299)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies. [PDF]

Epigenetics, 2022
Lussier AA, Zhu Y, Smith BJ, Simpkin AJ, Smith ADAC, Suderman MJ, Walton E, Ressler KJ, Dunn EC.   +8 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

BEAT: An Open-Source Web-Based Open-Science Platform [PDF]

, 2017
With the increased interest in computational sciences, machine learning (ML), pattern recognition (PR) and big data, governmental agencies, academia and manufacturers are overwhelmed by the constant influx of new algorithms and techniques promising ...
Anjos, André, El-Shafey, Laurent, Marcel, Sébastien   +2 more
core   +1 more source

Validez interna y reproducibilidad de la prueba CAGE en Bucaramanga, Colombia.

Biomédica: revista del Instituto Nacional de Salud, 2005
Objetivo. Evaluar la validez interna y la reproducibilidad de cutting down, annoyance by criticism, guilty feeling, and eye-openers (CAGE) en Bucaramanga, Colombia, de junio de 2002 a noviembre de 2003. Método.
Oscar F. Herrán, María F. Ardila
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Mathematical Surface Matching of Maps of the Human Torso [PDF]

, 2002
This report concerns with the collection and processing of data acquired from three-dimensional (3D) surface scans of scoliosis patients' backs. Two main issues were addressed: the reproducibility of the results, and stringent time constraints.
Orchard, Jeff, Webber, Adam
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

metajelo: A Metadata Package for Journals to Support External Linked Objects [PDF]

, 2019
We propose a metadata package that is intended to provide academic journals with a lightweight means of registering, at the time of publication, the existence and disposition of supplementary materials.
Lagoze, Carl, Vilhuber, Lars
core   +1 more source

Measuring reproducibility of high-throughput experiments

, 2011
Reproducibility is essential to reliable scientific discovery in high-throughput experiments. In this work we propose a unified approach to measure the reproducibility of findings identified from replicate experiments and identify putative discoveries ...
Bickel, Peter J., Brown, James B., Huang, Haiyan, Li, Qunhua   +3 more
core   +1 more source