Results 81 to 90 of about 1,138,858 (299)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Results of an attempt to reproduce the STAP phenomenon [PDF]
F1000Research, 2015 In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named ‘stimulus-triggered acquisition of pluripotency’ (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to chimera formation.
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Reproducibility, reliability and validity of measurements obtained from Cecile3 digital models
Brazilian Oral Research, 2009 The aim of this study was to determine the reproducibility, reliability and validity of measurements in digital models compared to plaster models. Fifteen pairs of plaster models were obtained from orthodontic patients with permanent dentition before ...
Gustavo Adolfo Watanabe-Kanno +4 more
doaj +1 more source
Reproducibility and replication of research results
International Journal on Software Tools for Technology TransferAbstract While a reproducible research result can be independently confirmed by third parties using artifacts provided by the original authors, replicating a research result means to independently obtain it using new measurements, data, or implementations.
Dirk Beyer, Arnd Hartmanns
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2020 Background: Clinical education and providing feedback are the most important criteria of vocational education in order to consolidate students' learning. Since evaluation of clinical teaching environment with using a suitable tool plays an important role
Marjan Jalali, Arash Najimi, Athar Omid
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Reproducibility of liquid oxygen impact test results [PDF]
Results for 12,000 impacts on a wide range of materials were studied to determine the reproducibility of the liquid oxygen impact test method. Standard deviations representing the overall variability of results were in close agreement with the expected ...
Gayle, J. B.
core +1 more source