Results 61 to 70 of about 166,851,649 (309)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nova validação semântico-cultural e estudo psicométrico da CASP-19 em adultos e idosos brasileiros

Cadernos de Saúde Pública, 2018
Os objetivos foram investigar indicadores psicométricos de validade de nova versão da CASP-19 para brasileiros com 55 anos e mais e estudar relações entre pontuações na escala e sexo, idade, escolaridade e status conjugal.
Anita Liberalesso Neri, Flávia Silva Arbex Borim, Samila Sathler Tavares Batistoni, Meire Cachioni, Dóris Firmino Rabelo, Arlete Portella Fontes, Mônica Sanches Yassuda   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The crossing-sign angle and trochlear dysplasia length: New radiographic parameters to measure the dysplastic trochleaWhat are the new findings?

Journal of ISAKOS
: Introduction: Trochlear dysplasia is one of the most relevant anatomic factors predisposing patients to patellofemoral instability and its recurrence. This study introduces two novel radiographic measurements: the crossing-sign angle and the trochlear
Juan Pablo Martinez-Cano, Juan Pablo Diaz-Solorzano, Jacobo Triviño-Arias, Andrea Valencia-Orozco, Maria Camila Gomez-Ayala, Marc Tompkins   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

First UK Reproducibility Network Annual Report (2023-2024) [PDF]

Il s\u27agit du rapport annuel 2023-2024 de l\u27UK Reproducibility Network (UKRN) au sujet de la Science Ouverte avec des exemples anglais de projets inspirant très ...
UK Reproducibility Network (UKRN)
core  

RELIABILITY OF A NEW BAROPODOMETRY PLATFORM DURING BAREFOOT WALKING IN HEALTHY ADULTS [PDF]

Acta Ortopédica Brasileira
Objective: To expand existing knowledge on gait parameters in a healthy population using a baropodometer and to ensure the reliability of the equipment.
Silvia Iovine Kobata, Cynthia Rossetti Portela Alves, Marcelo Grossi Araújo, Flavia Vasques Bittencourt   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Reproducibility, reliability and validity of measurements obtained from Cecile3 digital models

Brazilian Oral Research, 2009
The aim of this study was to determine the reproducibility, reliability and validity of measurements in digital models compared to plaster models. Fifteen pairs of plaster models were obtained from orthodontic patients with permanent dentition before ...
Gustavo Adolfo Watanabe-Kanno, Jorge Abrão, Hiroshi Miasiro Junior, Alfonso Sánchez-Ayala, Manuel O. Lagravère   +4 more
doaj   +1 more source