Results 71 to 80 of about 663,250 (267)

Reproducible Results Policy [PDF]

Journal of Water Resources Planning and Management, 2021
David E. Rosenberg, Amber Spackman Jones, Yves Filion, Rebecca Teasley, Samuel Sandoval-Solis, James H. Stagge, Adel Abdallah, Anthony Castronova, Avi Ostfeld, David Watkins   +9 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies. [PDF]

Epigenetics, 2022
Lussier AA, Zhu Y, Smith BJ, Simpkin AJ, Smith ADAC, Suderman MJ, Walton E, Ressler KJ, Dunn EC.   +8 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Adaptação transcultural, confiabilidade e validade da escala de resiliência

Cadernos de Saúde Pública
Busca-se apresentar os resultados da adaptação transcultural para o português da escala de resilência de Wagnild & Young e da avaliação psicométrica desta.
Renata P. Pesce, Simone G. Assis, Joviana Q. Avanci, Nilton C. Santos, Juaci V. Malaquias, Raquel Carvalhaes   +5 more
doaj  

Validez interna y reproducibilidad de la prueba CAGE en Bucaramanga, Colombia.

Biomédica: revista del Instituto Nacional de Salud, 2005
Objetivo. Evaluar la validez interna y la reproducibilidad de cutting down, annoyance by criticism, guilty feeling, and eye-openers (CAGE) en Bucaramanga, Colombia, de junio de 2002 a noviembre de 2003. Método.
Oscar F. Herrán, María F. Ardila
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Two universality results for polynomial reproducing kernels

Journal of Approximation Theory, 2017
We prove two new universality results for polynomial reproducing kernels of compactly supported measures. The first applies to measures on the unit circle with a jump and a singularity in the weight at $1$ and the second applies to area-type measures on a certain disconnected polynomial lemniscate.
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source