Results 141 to 150 of about 166,851,649 (309)
Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results. [PDF]
Mol Cell Proteomics, 2017 Bruderer R +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Reproducibility of results in preclinical studies: a perspective from the bone field. [PDF]
J Bone Miner Res, 2014 Manolagas SC, Kronenberg HM.
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Grand Rounds: Research Reproducibility - Ramkiran (Ram) Gouripeddi (12-05-2017)
, 2018 Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Reproducible Informatics for Reproducible Research" presented by Ramkiran Gouripeddi, MS, MBBS, Research Assistant Professor, Biomedical Informatics. Dr.
Ram Gouripeddi, MD
core
Reproducible Research Results R3
, 2014 Reproducible Research Results ...
TREFOIS, Christophe +5 more
openaire +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Grand Rounds Research Reproducibility - Mollie R. Cummins, PhD (03-13-2018)
, 2018 Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Peer Review and Research Reproducibility" video lecture by Mollie R.
Mollie R. Cummins, PhD
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source