Results 171 to 180 of about 1,138,858 (299)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

An international consensus on core reproducibility items in research. [PDF]

PLoS Biol
Banzi R, Varga M, Gelsleichter YA, Vinatier C, Moher D, Naudet F, OSIRIS-Delphi Study Group.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Lithium Isotopic Analysis of Spodumene by Secondary Ion Mass Spectrometry. [PDF]

Rapid Commun Mass Spectrom
Sharpe R, Fayek M, Luo JC.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Validação do questionário de avaliação funcional das mãos em hanseníase

Revista de Saúde Pública
OBJETIVO: Validar as propriedades psicométricas do questionário de avaliação funcional das mãos em hanseníase. MÉTODOS: Estudo realizado com amostra de conveniência de 101 pacientes consecutivos em Brasília, DF, de junho de 2008 a julho de 2009.
Telma Leonel Ferreira, Rosicler Rocha Aiza Alvarez, Marcos da Cunha Lopes Virmond   +2 more
doaj  

Impact of partial volume correction on radiomics reproducibility in theranostic SPECT/CT imaging. [PDF]

Med Phys
Azimi MS, Cheraghi M, Ghodsi Rad MA, Bayat M, Alhashim M, Dadgar H, Alabedi M, Ibrahim N, Alwuhaib E, Arabi H, Rahmim A, Zaidi H.   +11 more
europepmc   +1 more source

Research method in AI - Reproducibility of results

, 2017
Reproducibility of published computational research has seen increased interest the last twenty years. Regardless of academic field and the impact-factor of journals, studies of reproducibility of computational research have found low rates of reproducibility.
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Real-World Evaluation of an AI-Assisted Diagnostic Support System for Early Gastric Cancer: Diagnostic Performance, Confidence Stratification, and Determinants of False-Positive Diagnosis. [PDF]

J Clin Med
Osawa S, Yamada T, Inui W, Niwa T, Takahashi K, Egami T, Inagaki K, Takebe T, Ito T, Takahashi S, Onoue S, Asai Y, Sugiura K, Matsuura T, Ishida N, Yamade M, Iwaizumi M, Hamaya Y, Sugimoto K.   +18 more
europepmc   +1 more source