Results 191 to 200 of about 4,106,574 (383)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Highly Reproducible Bactericidal Activity Test Results by Using a Modified National Committee for Clinical Laboratory Standards Broth Macrodilution Technique

, 1999
Donna M. Hacek, Dana C. Dressel, Lance R. Peterson   +2 more
openalex   +1 more source

The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test–retest study [PDF]

, 2009
Esben Thade Petersen, Kim Mouridsen, Xavier Golay   +2 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

ELISPOT assays provide reproducible results among different laboratories for T-cell immune monitoring—even in hands of ELISPOT-inexperienced investigators [PDF]

, 2009
W. Zhang, Richard Caspell, Alexey Y. Karulin, Murrium Ahmad, Nacilla Haicheur, Ahmed Abdelsalam, K. Johannesen, Virginie Vignard, Paulina Dudzik, K. Georgakopoulou, A. Mihaylova, Karīna Siliņa, Natalia Aptsiauri, Val R. Adams, P. Lehmann, Stéphanie McArdle   +15 more
openalex   +1 more source

Accuracy, repeatability, and interplatform reproducibility of T1 quantification methods used for DCE‐MRI: Results from a multicenter phantom study

Magnetic Resonance in Medicine, 2018
Octavia Bane, S. Hectors, M. Wagner, Lori Arlinghaus, M. Aryal, Yue Cao, T. Chenevert, F. Fennessy, Wei Huang, N. Hylton, Jayashree Kalpathy-Cramer, K. Keenan, D. Malyarenko, R. Mulkern, D. Newitt, S. Russek, K. Stupic, A. Tudorica, L. Wilmes, T. Yankeelov, Yi-Fei Yen, M. Boss, B. Taouli   +22 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Arthroscopic Bankart-Bristow-Latarjet Procedure: The Development and Early Results of a Safe and Reproducible Technique [PDF]

, 2010
Pascal Boileau, Numa Mercier, Yannick Roussanne, Charles-Édouard Thélu, Jason Old   +4 more
openalex   +1 more source

RP-REP Ribosomal Profiling Reports: an open-source cloud-enabled framework for reproducible ribosomal profiling data processing, analysis, and result reporting [PDF]

, 2021
Travis L. Jensen, William F. Hooper, Sami R. Cherikh, Johannes B. Goll   +3 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source