Results 191 to 200 of about 1,492,841 (382)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Code and data to reproduce the results of the paper: "Land Use Patterns and Climate Change---A Modeled Scenario of the Late Bronze Age in Southern Greece"

, 2019
Daniel Knitter, Gerrit Günther, Wolfgang Hamer, Torben Keßler, Joana Seguin, Ingmar Unkel, Erika Weiberg, Rainer Duttmann, Oliver Nakoinz   +8 more
openalex   +2 more sources

Comparison of the reproducibility of results of a new peri-implantitis assessment system (implant success index) with the Misch classification. [PDF]

J Korean Assoc Oral Maxillofac Surg, 2014
Abrishami MR, Sabour S, Nasiri M, Amid R, Kadkhodazadeh M.   +4 more
europepmc   +1 more source

Assessment of Resolution and Intercenter Reproducibility of Results of Genotyping Staphylococcus aureus by Pulsed-Field Gel Electrophoresis of SmaI Macrorestriction Fragments: a Multicenter Study

Journal of Clinical Microbiology, 1998
A. van Belkum, W. V. van Leeuwen, M. Kaufmann, B. Cookson, F. Forey, J. Etienne, R. Goering, F. Tenover, Christine D. Steward, F. O'Brien, W. Grubb, P. Tassios, N. Legakis, A. Morvan, N. El Solh, R. de Ryck, M. Struelens, S. Salmenlinna, J. Vuopio‐Varkila, M. Kooistra, A. Talens, W. Witte, H. Verbrugh   +22 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Reproducing the results in 'Robot Dynamics Identification: A Reproducible Comparison With Experiments on the Kinova Jaco' [PDF]

Vladimir Sivtsov, Αλέξανδρος Παπανικολάου, Fabio Bonsignorio   +2 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Results of the ISMRM 2020 joint Reproducible Research& Quantitative MR study groups reproducibility challenge on phantomand human brain T1 mapping [PDF]

, 2023
Mathieu Boudreau, Agâh Karakuzu, Julien Cohen‐Adad, Ecem Bozkurt, Madeline Carr, Marco Castellaro, Luis Concha, Mariya Doneva, Seraina A. Dual, Alex Ensworth, Alexandru Foias, Véronique Fortier, Refaat E. Gabr, Guillaume Gilbert, Carri Glide‐Hurst, Matthew Grech‐Sollars, Siyuan Hu, Oscar Jalnefjord, Jorge Jovicich, Kübra Keskin, Peter Koken, Anastasia Kolokotronis, Simran Kukran, Nam G. Lee, Ives R. Levesque, Bochao Li, Dan Ma, Burkhard Mädler, Nyasha G. Maforo, Jamie Near, Erick H. Pasaye, Alonso Ramírez-Manzanares, Ben Statton, Christian Stehning, Stefano Tambalo, Ye Tian, Chenyang Wang, Kilian Weis, Niloufar Zakariaei, Shuo Zhang, Ziwei Zhao, Nikola Stikov   +41 more
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source