Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Inter- and intra-observer reliability of the Ergonomic Screening and Prioritization Tool to assess the risk level of work-related musculoskeletal disorders in nurses [PDF]
طب کارIntroduction: Musculoskeletal Disorders (MSDs) are among the most common occupational diseases, and ergonomics and occupational health engineering specialists need reliable and valid methods for assessing high-risk activities and the factors contributing
Niloofar Rahgoshay +4 more
doaj
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Plea for a Simple But Radical Change in Scientific Publication: To Improve Openness, Reliability, and Reproducibility, Let’s Deposit and Validate Our Results before Writing Articles [PDF]
, 2022 Jean‐Antoine Girault
openalex +1 more source
More adjustments of physical conditions for the control population might increase the credibility and reproducibility of the results [PDF]
, 2022 Xiaocun Xing, Jinlin Yang, Kai Deng
openalex +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Improving Reproducibility and Reuse of Modelling Results in the Life Sciences
, 2018 Research results are complex and include a variety of heterogeneous data. This entails major computational challenges to (i) to manage simulation studies, (ii) to ensure model exchangeability, stability and validity, and (iii) to foster communication between partners.
openaire +3 more sources
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, Volume 15, Issue 6, Page 963-971, June 2025.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source