Results 91 to 100 of about 614,762 (328)
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Journal of Open Research Software, 2014 The goal of this article is to coalesce a discussion around best practices for scholarly research that utilizes computational methods, by providing a formalized set of best practice recommendations to guide computational scientists and other stakeholders
Victoria Stodden, Sheila Miguez
doaj +1 more source
Using the IPOL Journal for Online Reproducible Research in Remote Sensing
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020 Reproducible research is needed to ensure that scientific results in the literature are reliable, unbiased, and verifiable by others. The journal Image Processing On Line (IPOL) publishes reproducible articles since 2010.
Miguel Colom +5 more
doaj +1 more source
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Thermostats: an Open Source Shiny App for Your Open Data Repository
JOIV: International Journal on Informatics Visualization, 2019 Hydrochemical analysis has emerged as a powerful methodology in geothermal system profiling. Indonesia is the capital of geothermal energy with its more than 100 active volcanoes.
Dasapta Erwin Irawan +3 more
doaj +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Reproducible Pattern Recognition Research: The Case of Optimistic SSL [PDF]
arXiv, 2016 In this paper, we discuss the approaches we took and trade-offs involved in making a paper on a conceptual topic in pattern recognition research fully reproducible. We discuss our definition of reproducibility, the tools used, how the analysis was set up, show some examples of alternative analyses the code enables and discuss our views on ...
arxiv
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source