Results 121 to 130 of about 871,682 (287)

Introduction to Reproducible Geospatial Analysis and Figures in R: A Tutorial Article

Data
The present article is intended to serve an educational purpose for data scientists and students who already have experience with the R language and which to start using it for geospatial analysis and map creation.
Philippe Maesen, Edouard Salingros
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The NCI Imaging Data Commons as a platform for reproducible research in computational pathology. [PDF]

Comput Methods Programs Biomed, 2023
Schacherer DP, Herrmann MD, Clunie DA, Höfener H, Clifford W, Longabaugh WJR, Pieper S, Kikinis R, Fedorov A, Homeyer A.   +9 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Arc driver operation for either efficient energy transfer or high-current generator [PDF]

An investigation is made to establish predictable electric arcs along triggered paths for research purposes, the intended application being the heating of the driver gas of a 1 MJ electrically driven shock tube.
Dannenberg, R. E., Silva, A. F.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Pragmatic reproducible research: improving the research process from raw data to results, bit by bit. [PDF]

J Clin Invest, 2023
Rasmussen LV, Whitley EW, Welty LJ.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Riffomonas YouTube Channel: An Educational Resource To Foster Reproducible Research Practices. [PDF]

Microbiol Resour Announc, 2023
Schloss PD.
europepmc   +1 more source