Results 141 to 150 of about 871,682 (287)

Ten simple rules for implementing open and reproducible research practices after attending a training course. [PDF]

PLoS Comput Biol, 2023
Heise V, Holman C, Lo H, Lyras EM, Adkins MC, Aquino MRJ, Bougioukas KI, Bray KO, Gajos M, Guo X, Hartling C, Huerta-Gutierrez R, Jindrová M, Kenney JPM, Kępińska AP, Kneller L, Lopez-Rodriguez E, Mühlensiepen F, Richards A, Richards G, Siebert M, Smith JA, Smith N, Stransky N, Tarvainen S, Valdes DS, Warrington KL, Wilpert NM, Witkowska D, Zaneva M, Zanker J, Weissgerber TL.   +31 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Data Management: The First Step in Reproducible Research.

Indian J Occup Environ Med, 2023
Soundararajan S, Mishra S.
europepmc   +1 more source

Running a research group in the next generation: combining sustainable and reproducible research with values-driven leadership. [PDF]

J Exp Bot, 2023
Monaghan J, Brady SM, Haswell ES, Roy S, Schwessinger B, McFarlane HE.   +5 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A community-led initiative for training in reproducible research. [PDF]

Elife, 2021
Auer S, Haeltermann NA, Weissberger TL, Erlich JC, Susilaradeya D, Julkowska M, Gazda MA, Schwessinger B, Jadavji NM, Reproducibility for Everyone Team.   +9 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Teaching reproducible research for medical students and postgraduate pharmaceutical scientists. [PDF]

BMC Res Notes, 2021
Meid AD.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Research Data Management and Data Sharing for Reproducible Research-Results of a Community Survey of the German National Research Data Infrastructure Initiative Neuroscience. [PDF]

eNeuro, 2023
Klingner CM, Denker M, Grün S, Hanke M, Oeltze-Jafra S, Ohl FW, Radny J, Rotter S, Scherberger H, Stein A, Wachtler T, Witte OW, Ritter P.   +12 more
europepmc   +1 more source