Results 141 to 150 of about 418,446 (282)

BITSS Research Transparency and Reproducibility Training (RT2) Virtual 2021

, 2021
Aleksandar Bogdanoski, Katie Hoeberling, Fernando Hoces de la Guardia, Edward Miguel, Leif D. Nelson, Alexander Coppock, Cecilia Hyunjung Mo, Ciera Christin Martinez, Lars Vilhuber, Luíza Cardoso de Andrade, Mo, Cecilia Hyunjung, Martin, Luis Eduardo San, Bogdanoski, Aleksandar, Vollmer, Timothy, Jui Paithane, Daniels, Benjamin   +15 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Developing and deploying an integrated workshop curriculum teaching computational skills for reproducible research. [PDF]

J Open Source Educ, 2022
Lapp Z, Sovacool KL, Lesniak N, King D, Barnier C, Flickinger M, Krüger J, Armour CR, Lapp MM, Tallant J, Diao R, Oneka M, Tomkovich S, Anderson JM, Lucas SK, Schloss PD.   +15 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A173 LACK OF EXPERIMENTAL REPRODUCIBILITY IN PRECLINICAL RESEARCH: FOCUS ON DIETARY CONTENT OF FERMENTABLE CARBOHYDRATE (FODMAPS) IN STANDARD RODENT CHOWS [PDF]

, 2019
Caroline J. Tuck, Kaede Takami, David E. Reed, Jane G. Muir, Giada De Palma, Přemysl Berčík, Elena F. Verdú, Stephen Vanner   +7 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A Multi-Language Computing Environment for Literate Programming and Reproducible Research

Journal of Statistical Software, 2012
We present a new computing environment for authoring mixed natural and computer language documents. In this environment a single hierarchically-organized plain text source file may contain a variety of elements such as code in arbitrary programming ...
Eric Schulte, Dan Davidson, Thomas Dye, Carsten Dominik   +3 more
doaj  

Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration. [PDF]

BMC Med Inform Decis Mak, 2023
Abbasizanjani H, Torabi F, Bedston S, Bolton T, Davies G, Denaxas S, Griffiths R, Herbert L, Hollings S, Keene S, Khunti K, Lowthian E, Lyons J, Mizani MA, Nolan J, Sudlow C, Walker V, Whiteley W, Wood A, Akbari A, CVD-COVID-UK/COVID-IMPACT Consortium.   +20 more
europepmc   +1 more source

Heterogeneous Optimization Framework: Reproducible Preprocessing of Multi-Spectral Clinical MRI for Neuro-Oncology Imaging Research

, 2016
Mikhail Milchenko, Abraham Z. Snyder, Pamela LaMontagne, Joshua S. Shimony, Tammie L.S. Benzinger, Sarah Jost Fouke, Daniel S. Marcus   +6 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source