Results 181 to 190 of about 418,446 (282)

Ten simple rules for implementing open and reproducible research practices after attending a training course

, 2022
Verena Heise, Constance Holman, Hung Lo, Ekaterini Maria Lyras, Mark Christopher Adkins, Maria Raisa Jessica Aquino, Konstantinos I. Bougioukas, Katherine O. Bray, Martyna Gajos, Xuánzōng Guō, Corinna Hartling, Rodrigo Huerta-Gutiérrez, Miroslava Jindrová, Joanne Kenney, Adrianna P. Kępińska, Laura Kneller, Elena López-Rodríguez, Felix Mühlensiepen, Angela Richards, Gareth Richards, Maximilian Siebert, James Smith, Natalie Smith, Nicolai Stransky, Sirpa Tarvainen, Daniela S. Valdes, Kayleigh L. Warrington, Nina‐Maria Wilpert, Disa Witkowska, Mirela Zaneva, Jeanette Zanker, Tracey L. Weissgerber   +31 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Strategies to enable large-scale proteomics for reproducible research. [PDF]

Nat Commun, 2020
Poulos RC, Hains PG, Shah R, Lucas N, Xavier D, Manda SS, Anees A, Koh JMS, Mahboob S, Wittman M, Williams SG, Sykes EK, Hecker M, Dausmann M, Wouters MA, Ashman K, Yang J, Wild PJ, deFazio A, Balleine RL, Tully B, Aebersold R, Speed TP, Liu Y, Reddel RR, Robinson PJ, Zhong Q.   +26 more
europepmc   +1 more source

How to: Dynamic Reports and Reproducible Research

Toghrul Aghbabali, Wan Soo Choi, T. Im, Dominik Rösch, P. Roy   +4 more
openalex   +1 more source

Reproducible Research

Computing in Science & Engineering, 2010
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Against All Odds: Why a Lung Donor Score Does Not Add Up

Transplant International
Simon Schwab, Simon Schwab, Fabian Iten
doaj   +1 more source

Reproducible research practices: A tool for effective and efficient leadership in collaborative statistics. [PDF]

Stat
Hochheimer CJ, Bosma GN, Gunn-Sandell L, Sammel MD.   +3 more
europepmc   +1 more source

Assessment of transparent and reproducible research practices in the psychiatry literature. [PDF]

Gen Psychiatr, 2020
Sherry CE, Pollard JZ, Tritz D, Carr BK, Pierce A, Vassar M.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source