Results 131 to 140 of about 1,070,079 (313)

Under what conditions is uterine myoma in women of reproductive age associated with the use of combined oral contraceptives?

Acta Biomedica Scientifica
Uterine myoma (UM) is a common benign tumor of smooth muscle cells of the myometrium, which is often associated with metabolic disorders. Hormonal contraceptives are used to control the duration and volume of menstrual bleeding in UM.
N. I. Babaeva, Ia. G. Nadeliaeva, I. N. Danusevich, L. M. Lazareva, I. Yu. Egorova, A. V. Atalyan, I. A. Igumnov, K. D. Ievleva, L. V. Suturina   +8 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

SARS-CoV-2 viral load in newborns with COVID-19

Якутский медицинский журнал
The aim. Investigation of nasopharyngeal SARS-CoV-2 viral load in newborns with COVID-19 of different severity.Materials and methods. The main group was composed of 44 newborns with RT-PCR confirmed COVID-19.
A. A. Parshina, Ye. V. Moskaleva, A. G. Petrova, L. V. Rychkova, O. B. Ogarkov, E. A. Orlova, A. S. Vanyarkina, E. A. Novikova, E. D. Kasantseva   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intracellular Levels of Reactive Oxygen Species In Developing Mouse Embryos. [PDF]

, 2009
42nd Annual Meeting of the Society-for-the-Study-of-Reproduction -- JUL 18-22, 2009 -- Pittsburgh, PAWOS: 000273605500229…Soc Study Reproduct, David L Lawrence Convent ...
Dikmen, Nurten, Leventerler, Hulya, Erdogan, Seref   +2 more
core  

Seasonality in Reproduction and Reproductive Physiology of Caviomorphs

Mammal Review
ABSTRACT Animals experience seasonal fluctuations of photoperiod, food availability, temperature and precipitation. This affects their energy budget, often leading to seasonal reproduction. We review available literature and (re)‐analyse existing datasets on seasonal reproduction of South American caviomorph rodents that are characterised by long ...
Anja Guenther, Patricia Tachinardi, Veronica Sandra Valentinuzzi, Raúl Sobrero, Ayelen T. Eberhardt, Fritz Trillmich   +5 more
openaire   +3 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source