Results 21 to 30 of about 590,437 (267)

Markers of oxidative damage lipids and DNA in men with type 1 diabetes mellitus and different levels of albuminuria

Сахарный диабет, 2022
BACKGROUND: Diabetic nephropathy is a specific kidney damage that affects up to 40% of type 1 diabetes mellitus patients. There is still insufficient knowledge about oxidative stress at the different levels of albuminuria.AIM: To assess the indicators of
M. A. Darenskaya, E. V. Chugunova, S. I. Kolesnikov, L. A. Grebenkina, N. V. Semenova, O. A. Nikitina, L. I. Kolesnikova   +6 more
doaj   +1 more source

New national outcome data on fresh versus cryopreserved donor oocytes

Journal of Ovarian Research, 2018
Background Improvements in oocyte cryopreservation techniques and establishment of cryopreserved donor oocyte banks have led to improved access to and lower cost of donor oocytes, upending the traditional practice of fresh oocyte donation.
Vitaly A. Kushnir, Sarah K. Darmon, David H. Barad, Norbert Gleicher   +3 more
doaj   +1 more source

Intraovarian Injection of Lyophilized Platelet-Rich Plasma in Patients with Poor Ovarian Response

Fertility & Reproduction
Objective: To demonstrate the effect of intraovarian injection of lyophilized platelet-rich plasma (PRP) in poor ovarian responders. Methods: This retrospective cohort study evaluated data for 262 women who underwent intraovarian injection of lyophilized
Aya Karino, Hidehiko Matsubayashi, Saki Saito, Yurino Ishibashi, Kento Usui, Masakazu Doshida, Takumi Takeuchi, Yosuke Suzuki, Yasuhiro Ohara, Tomomoto Ishikawa   +9 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Does air pollution play a role in infertility?: a systematic review

Environmental Health, 2017
Background Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through ...
Julie Carré, Nicolas Gatimel, Jessika Moreau, Jean Parinaud, Roger Léandri   +4 more
doaj   +1 more source

Correlation between actual nutrition and lipid peroxidation and antioxidant defense parameters in aged 14–17 years adolescents living in rural area

Сибирский научный медицинский журнал, 2022
The aim of the study was to reveal the relationship between the parameters of actual nutrition and the lipid peroxidation and antioxidant defense system in adolescents aged 14–17 in a rural area. Material and methods.
M. A. Darenskaya, L. V. Rychkova, T. A. Astakhova, A. V. Pogodina, O. N. Dolgikh, Yu. N. Klimkina, L. I. Kolesnikova   +6 more
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

UGT2B17 genotype and the pharmacokinetic serum profile of Testosterone during substitution therapy with Testosterone Undecanoate. A retrospective experience from 207 men with hypogonadism.

Frontiers in Endocrinology, 2013
BackgroundTestosterone (T) is mainly excreted in the urine as testosterone glucuronide (TG). This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion.
Anne Kirstine eBang, Niels eJørgensen, Ewa eRajpert-De Meyts, Anders eJuul   +3 more
doaj   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source