Results 111 to 120 of about 5,005,502 (303)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Mechanisms and therapeutic effects of granulocyte colony-stimulating factor in reproduction

Reproductive Biology and Endocrinology
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that is primarily secreted by monocytes or macrophages and has traditionally been recognized for its role in stimulating the proliferation and differentiation of neutrophils ...
Lu Zhou, Liming Zhou
doaj   +1 more source

Depletion and social reproduction [PDF]

, 2011
Much work has been done on the unaccounted contribution of social reproductive work to national economies. What has been less studied is the consequence of this neglect for individuals, households and communities engaged in social reproduction.
Thomas, Dania, Rai, Shirin, Hoskyns, Catherine   +2 more
core  

Erratum: Expression of fibroblast growth factor-8 and regulation of cognate receptors, fibroblast growth factor receptor-3c and -4, in bovine antral follicles (Reproduction vol. 130 (347))

, 2005
Departamento de Reprodução Animal Faculdade de Medicina Veterinária Universidade Estadual Paulista, Botucatu, São PauloDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, São PauloCentre de Recherche en ...
Costa, I. B. [UNESP], Giometti, I. C. [UNESP], Glapinski, V. F. [UNESP], Nicola, E. S., Pinto, M. G. [UNESP], Teixeira, A. B. [UNESP], Barros, C. M. [UNESP], Cao, M., Price, C. A., Buratini, J. [UNESP]   +9 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Âl Hallingdal Door Reproduction

, 1880
Detail, showing the carving at the top of the portal opening; The original object is from the Church of Âl, in Hallingdal, now in the Universitetets Oldsaksamling, Oslo, Norway, is wood and dates from ca. 1150-1175.
after unknown (Norse sculptor), unknown (reproduction firm)   +1 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A winged-helix DNA-binding protein is essential for self-fertility during sexual development of the homothallic fungus Fusarium graminearum

mSphere
Sexual reproduction is crucial for increasing the genetic diversity of populations and providing overwintering structures, such as perithecia and associated tissue, in the destructive plant pathogenic fungus Fusarium graminearum.
Jiyeun Park, Hosung Jeon, Aram Hwangbo, Kyunghun Min, Jaeho Ko, Jung-Eun Kim, Sieun Kim, Ji Young Shin, Yong-Hwan Lee, Yin-Won Lee, Hokyoung Son   +10 more
doaj   +1 more source

ASSISTED HUMAN REPRODUCTION: PSYCHOLOGICAL AND ETHICAL DILEMMAS

, 2003
Contributors -- Foreword / Professor Susan Golombok -- Introduction -- Ch. 1. Assisted human reproduction: contemporary policy and practice in the UK / Eric Blytb, Nina Martin and Claire Potter -- Ch. 2. Issues of gamete donation and sex selection: a

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