Results 81 to 90 of about 5,005,502 (303)

The net reproduction rate and the type-reproduction number in multiregional demography [PDF]

In order to study effects of migration on demographic changes of multiregional populations, multiregional population modelling is a useful traditional tool.
Hisashi Inaba
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Response of lettuce cultivars to Meloidogyne javanica and Meloidogyne incognita race 1 and 2

Revista Ciência Agronômica
The aim of this study was to evaluate resistance to Meloidogyne javanica and Meloidogyne incognita race 1 and 2 in the American group of lettuce cultivars.
Érika Cristina Souza da Silva Correia, Norberto da Silva, Marylia Gabriella Silva Costa, Silvia Renata Siciliano Wilcken   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Involvement of gonadal soma-derived factor in the reproduction of teleosts

Aquaculture and Fisheries
Gonadal soma-derived factor (Gsdf) is a member of the transforming growth factor beta (TGF-β) superfamily and a teleost-specific gene. Early studies suggested that Gsdf promotes spermatogonial proliferation; however recent reports have shed light on its ...
Tohru Kobayashi
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of Italian legislation regulating assisted reproduction techniques on ICSI outcomes in severe male factor infertility: A multicentric survey

, 2007
Background: In 2004, a law regulating assisted reproduction techniques (ART) was passed in Italy. The new rules allow for the formation and transfer of a maximum of three embryos at one time, whereas embryo selection and embryo storage are prohibited ...
L. De Santis, G. Ragni, LOMBARDO, Francesco, GRECO E., E. Greco, M. L. Papale, COSTA M, CELA V, ARTINI, PAOLO GIOVANNI, A. Revelli, I. Cino, RACCA C, P. G. Artini, GANDINI, Loredana, DIOTALLEVI L, L. Rienzi, M. Dusi, C. Racca, D'AMBROGIO G, M. Costa, RAGNI G, R. Ciriminna, L. Parmegiani, CIRIMINNA R, GENAZZANI, ANDREA, Italian Society O. F. Embriology, GIUFFRIDA G, RIENZI L, DE SANTIS L, L. Diotallevi, V. Cela, G. D'Ambrogio, ITALIAN SOCIETY OF EMBRIOLOGY, DUSI M, PARMEGIANI L, BARBARO R, REVELLI A, M. Filicori, Reproduction, Research, GANDINI L, R. Barbaro, REPRODUCTION AND RESEARCH, A. R. Genazzani, LOMBARDO F, CINO I, PAFFONI A, D. Colia, G. Giuffrida, A. Paffoni, COLIA D, FILICORI M, PAPALE ML   +51 more
core   +1 more source

how reproduction in captivity can help an endangered species [PDF]

, 2023
openPartendo dalla biologia della specie del giaguaro, focalizzandomi sulla sua riproduzione in natura, faccio una comparazione su come può avvenire in cattività.
BARACHETTI, SERENA
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source