Results 1 to 10 of about 1,125,232 (289)
Paternal age and reproduction [PDF]
Human Reproduction Update, 2009 Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome ...
Sartorius, Gideon A. +1 more
openaire +3 more sources
Innovation in Aging, 2023 Abstract Reproductive aging is a major health, personal and societal issue, but ovarian aging has received limited scientific attention. Ovarian aging has been known to influence diverse health outcomes in women including lifespan, cardiovascular disease, metabolic syndromes, neurodegenerative disorders and various types of cancer.
openaire +1 more source
Reproductive ageing in women [PDF]
The Journal of Pathology, 2007 AbstractThe traditional view in respect to female reproduction is that the number of oocytes at birth is fixed and continuously declines towards the point when no more oocytes are available after menopause. In this review we briefly discuss the embryonic development of female germ cells and ovarian follicles.
O, Djahanbakhch, M, Ezzati, A, Zosmer
openaire +2 more sources
Telomere length and reproductive aging [PDF]
Human Reproduction, 2009 Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence.Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i)
Hanna, Courtney W. +5 more
openaire +2 more sources
The ageing male reproductive tract [PDF]
The Journal of Pathology, 2007 AbstractAgeing of the male reproductive system is characterized by changes in the endocrine system, hypogonadism, erectile dysfunction and proliferative disorders of the prostate gland. Stochastic damage accumulating within ageing leads to progressive dysregulation at each level of the hypothalamic–pituitary–gonadal (HPG) axis and in local auto ...
N, Sampson +3 more
openaire +2 more sources
Metabolism in Male Reproductive Aging
Advances in Geriatric Medicine and Research, 2021 Similar to female reproductive health, male reproductive health declines with increasing age, albeit in a more gradual way. In the US, the average age of first-time fathers has been steadily increasing since 1980. This is concerning because increasing paternal age is positively correlated with reduced sperm chromatin quality and higher numbers of DNA ...
Meyer, Ralph G., Meyer-Ficca, Mirella L.
openaire +2 more sources
Oncotarget, 2015 Inherited defects in DNA repair are rare genetic conditions characterized by hypersensitivity to endogenous and exogenous DNA damage. Double-strand break (DSB) is the most severe form of DNA damage which can induce gross chromosomal rearrangements such as translocations, deletions, duplications, and complex genomic aberrations, triggering permanent ...
Svetlana A, Yatsenko +1 more
openaire +2 more sources
Autoimmune diseases and reproductive aging [PDF]
Clinical Immunology, 2013 As the population ages, more individuals with autoimmune diseases are experiencing reproductive senescence. Understanding the impact of menopause and age-related androgen decline on disease onset and course, as well as the potential for hormonal interventions, is critically important.
openaire +2 more sources
Editorial: Ovarian aging and reproduction
Frontiers in Endocrinology, 2022 Mengyu Liu +4 more
openaire +3 more sources