Results 121 to 130 of about 1,125,232 (289)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Simulation of reproductive risk and emergence of female reproductive cessation

, 2002
Using a simple computer model for evolution, we show that in a sexual population subject only to age-increasing reproductive risk, a cessation of female reproduction emerges.Comment: 11 pages including 3 ...
A.O. Sousa, Austad, Charlesworth, Charlesworth, Eigen, Galambor, Hawkes, Hawkes, Howard, Kirkwood, Kirkwood, Laws, Makowiec, Marsh, Meyer-Ortmanns, Moss de Oliveira, Moss de Oliveira, Mueller, Packer, Penna, Redfield, Rochat, Shanley, Siller, Sousa, Stauffer, Takahata, Williams   +27 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Effects of age, density, and seasonality on molt pattern in the mammal genus (Peromyscus) [PDF]

, 2015
Molting, or replacement of pelage (hair) in mammals, occurs during ontogeny as individuals transition from juveniles to adults. Environmental factors can cause variation in molt in many species for thermoregulatory and camouflage purposes.
Graves, Rebecca Catherine
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate

, 2017
Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and production of viral particles.
Cervantes-Pérez, Ángel, Ávila-Vales, Eric   +1 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Reproductive Risk Factors for Breast Cancer: A Case Control Study [PDF]

, 2009
Background: Breast cancer is second most important cancer among Indian women. Although risk factors are not much prevalent as in western countries, incidence rate is increasing in India.
Hiwarkar, PA, Kulkarni, PN, Meshram, II
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Determinants of reproductive tract infection among fertile women in rural and urban areas of Eastern Gujarat: A community-based study

​​​One Health Bulletin
Objective: This study aimed to determine the prevalence of reproductive tract infections (RTIs) among fertile women in rural and urban areas. Methods: A systematic random sampling was conducted in women aged 15-49 years from rural and urban areas in ...
Bhavna Vasant Dhakate, Grishma Chauhan, Bhargav Rana, Khantil Gohil, Neelabh Pankaj, Niraj Pandit   +5 more
doaj   +1 more source