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DRP1 in reproduction and reproductive aging

Biology of Reproduction
Abstract Dynamin-related protein 1 (DRP1) is a central regulator of mitochondrial fission and plays a critical role in maintaining mitochondrial function, distribution, and turnover in reproductive cells. Mitochondrial integrity is essential for oocyte quality, folliculogenesis, fertilization, embryonic development, and ultimately ...
Cheng-Rung Huang   +4 more
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Reproductive ageing and the menopause

The International Journal of Developmental Biology, 2001
This brief review describes early work initiated by Anne McLaren and John Biggers, in which they repeated on mice a very early experiment carried out by John Hunter on pigs, to test the effect of unilateral ovariectomy on subsequent breeding performance.
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Age and reproduction

Reproductive Medicine Review, 1999
Advanced female reproductive age is an important factor when evaluating couples for infertility. Infertility is defined as a lack of pregnancy after 12 months of unprotected intercourse, a condition present in about 15% of couples of reproductive age. The proportion of couples considered infertile has not changed recently in spite of an increase in the
José R Cruz, Paul R Gindoff
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Aging of the male reproductive system

Experimental Gerontology, 2000
Reproductive and sexual physiology, changes in body composition and mental performance in the aging male cannot simply be reduced to presumptive hypogonadism defined by low androgen serum levels or by decreasing levels of growth hormone (GH) and melatonin.
M, Hermann   +3 more
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The aging reproductive neuroendocrine axis

Steroids, 2005
It is well known that the reproductive system is one of the first biological systems to show age-related decline. While depletion of ovarian follicles clearly relates to the end of reproductive function in females, evidence is accumulating that a hypothalamic defect is critical in the transition from cyclicity to acyclicity. This minireview attempts to
Darrell W, Brann, Virendra B, Mahesh
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Neuroendocrine concomitants of reproductive aging

Experimental Gerontology, 1994
Depletion of ovarian follicles is often thought to be the determining factor in female reproductive aging. However, increasing evidence suggests that neural and neuroendocrine changes play important causative roles in the decline of regular reproductive cycles leading to the menopause.
P M, Wise   +7 more
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Reproductive aging in female birds

Experimental Gerontology, 2003
Birds are underutilized as animal models for studying the basis of longevity, cellular adaptations for resisting oxidative damage, and delayed reproductive senescence. Reproductive aging patterns in female birds range from slightly slower than those in rodents of similar size to extremely slow or even negligible.
Donna J, Holmes   +3 more
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Reproductive Ageing

2009
Reproductive ageing affects both individuals and wider society, and obstetricians and gynaecologists are witness to the impact of reproductive ageing and to some of the fears and misapprehensions of the general public. This book raises awareness of societal trends and their implications.
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The Aging Male Reproductive System

Endocrinology and Metabolism Clinics of North America, 1995
The frequency of sexual activity declines dramatically with age, but this cannot be attributed, with any degree of certainty, to the rather modest hormonal and spermatogenic changes observed with advancing age. Despite the development of intrinsic age-related defects at all levels of the hypothalamic-pituitary-testicular axis, reproductive capacity is ...
P D, Tsitouras, T, Bulat
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REPRODUCTIVE FUNCTION IN THE AGING MALE

Urologic Clinics of North America, 1994
Although the association between advanced paternal age and serious birth defects has received less attention than the effect of maternal age on such defects, this association has been demonstrated. This, as well as the potential decline in fertility among older men, should be borne in mind by men electing to defer establishing a family.
R B, Meacham, M J, Murray
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