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Reproductive aging in female birds
Experimental Gerontology, 2003Birds are underutilized as animal models for studying the basis of longevity, cellular adaptations for resisting oxidative damage, and delayed reproductive senescence. Reproductive aging patterns in female birds range from slightly slower than those in rodents of similar size to extremely slow or even negligible.
Donna J, Holmes +3 more
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Neuroendocrine concomitants of reproductive aging
Experimental Gerontology, 1994Depletion of ovarian follicles is often thought to be the determining factor in female reproductive aging. However, increasing evidence suggests that neural and neuroendocrine changes play important causative roles in the decline of regular reproductive cycles leading to the menopause.
P M, Wise +7 more
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Telomeres and Female Reproductive Aging
Seminars in Reproductive Medicine, 2015Reproductive aging involves declines both in oocyte number and developmental capacity. Declining oocyte number alone cannot explain the manifestations of reproductive aging in women. We have proposed the Telomere Theory of Reproductive Aging to explain the complex phenotype found in oocytes from older women.
Keri Horan, Kalmbach +3 more
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The aging reproductive neuroendocrine axis
Steroids, 2005It is well known that the reproductive system is one of the first biological systems to show age-related decline. While depletion of ovarian follicles clearly relates to the end of reproductive function in females, evidence is accumulating that a hypothalamic defect is critical in the transition from cyclicity to acyclicity. This minireview attempts to
Darrell W, Brann, Virendra B, Mahesh
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The Aging Male Reproductive System
Endocrinology and Metabolism Clinics of North America, 1995The frequency of sexual activity declines dramatically with age, but this cannot be attributed, with any degree of certainty, to the rather modest hormonal and spermatogenic changes observed with advancing age. Despite the development of intrinsic age-related defects at all levels of the hypothalamic-pituitary-testicular axis, reproductive capacity is ...
P D, Tsitouras, T, Bulat
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Obstetrics and Gynecology Clinics of North America, 2018
Nanette Santoro, Howard M. Kravitz
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Nanette Santoro, Howard M. Kravitz
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Reproductive Hormones, Aging, and Sleep
Seminars in Reproductive Medicine, 1999Insomnia, disturbed sleep, and fatigue are among the most frequent health complaints of perimenopausal women. Estrogen replacement therapy (ERT) usually improves sleep, most likely by alleviating vasomotor symptoms. However, sleep difficulties are not restricted to the perimenopausal period.
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Skeletal Implications of Reproductive Aging
Seminars in Reproductive Medicine, 2010The skeleton's density (mineral content and strength) is due to genetics (~60%), nutrition (~20%), and sex hormones (20%). The last factor increases bone density at puberty, mostly due to estrogen production. During reproductive aging as the ovaries lose most of their follicles, estrogen production declines.
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