Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Comparing the Effects of Virtual Education and Self-Learning Methods on Childbearing Motivation Before Marriage: An Interventional Study [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Implementing educational programs that enhance attitudes and foster positive psychological norms can play a major role in increasing fertility intentions.
Sanaz Bahrami samani +4 more
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Resistance Monitoring of Nilaparvata lugens to Pymetrozine Based on Reproductive Behavior. [PDF]
Insects, 2023 Song XY +7 more
europepmc +1 more source
Adolescent childbearing experiences in Kenya: geographical and socioeconomic determinants [PDF]
Sub-Saharan Africa has one of the highest level of teenage pregnancies in the world. Some studies on this topic highlight the presence of unmet reproductive health needs of adolescent in different regions.
Angelina Mazzocchetti +3 more
core +1 more source
Sex, Reason, and a Taste for the Absurd [PDF]
, 1993 Like much of Richard Posner\u27s best work, Sex and Reason does many things, and for that reason will no doubt attract a large and diverse readership.
West, Robin
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Breeding Season and Movement Ecology of Male White‐Tailed Deer in Southwest Wisconsin
Ecology and EvolutionWhite‐tailed deer (Odocoileus virginianus; hereafter, deer) have been widely studied regarding their breeding ecology and responses to hunting pressures.
Matthew A. Hunsaker +3 more
doaj +1 more source
Changes in reproductive behavior associated with the perception and individual experiences of the COVID-19 pandemic. [PDF]
PLoS One, 2023 Slabá J.
europepmc +1 more source
Behavioral Ecology of an Invasive Species: Habitat and Mate Preference(s) in Drosophila Suzukii [PDF]
, 2017 The invasive Spotted-Wing fruit fly, Drosophila suzukii, has inflicted substantial economic losses to the soft-fruit agriculture industry worldwide due to the ability of females in this species to use a large, serrated ovipositor to cut the fruit’s skin ...
Buckiewicz, Natasha +2 more
core +1 more source