Results 201 to 210 of about 290,067 (258)

Length-weight relationship, condition factors and reproductive biology of the spineless cuttlefish Sepiella inermis (Ferussac & d'Orbigny, 1848) in the southeastern regions of the Bay of Bengal, Bangladesh. [PDF]

Heliyon
Jahan R, Mahmud MN.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Reproductive Biology and Rearing Improvements of Apanteles opuntiarum, Potential Biocontrol Agent of the Argentine Cactus Moth, Cactoblastis cactorum. [PDF]

Insects
Varone L, Benda N, Guala ME, Martínez JJ, Bruzzone OA.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

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Reproductive biology in the era of genomics biology

Theriogenology, 2005
Current and emerging technologies in reproductive biology, including assisted reproductive technologies and animal cloning, are discussed in the context of the impact of genomics era biology. The discussion focuses on the endocrinology associated with establishment and maintenance of pregnancy, fetal-placental development, lactation, and neonatal ...
Fuller Bazer, Thomas Spencer
exaly   +3 more sources

Reproductive Biology

2013
Abstract This chapter focuses on the floral development, fruit development and avocado tree phenology under various climatic conditions. The importance of increasing flowering, fruit set, yield and mitigating irregular bearing to increase fruit production is also discussed.
S. Salazar-García, L. C. Garner, C. J. Lovatt   +2 more
  +4 more sources

Reproductive biology of seals

Reviews of Reproduction, 1997
The reproductive biology of seals is fascinating in many aspects. As in most mammals, the time of onset of puberty in seals is variable. Once sexually mature, most but not all seals are seasonally mono-oestrous, with highly synchronized breeding seasons.
openaire   +2 more sources

The reproductive biology of schistosomes

Parasitology Today, 1986
Etude de la maturation femelle, de la stimulation, du mâle, des facteurs hotes et de l ...
openaire   +2 more sources