Results 51 to 60 of about 2,415,924 (290)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

IDENTIFICAÇÃO DO CIRCOVÍRUS SUÍNO TIPO 2 E DO PARVOVÍRUS SUÍNO EM FETOS SUÍNOS NATIMORTOS E MUMIFICADOS PROVENIENTES DE GRANJAS NO BRASIL

Ciência Animal Brasileira, 2010
This study investigated the presence of genome sequences of the porcine circovirus type 2 (PCV2) and porcine parvovirus (PPV) in 147 porcine stillbirths and mummified fetuses.
Danilo Leal Rocha, Geraldo Camilo Alberton, José Lúcio dos Santos   +2 more
doaj  

Protective effect of Vitamin E against Glyphosate-induced Reproductive failure in Female Rats [PDF]

Journal of Advanced Biomedical Sciences, 2021
Background & Objective: The glyphosate-based herbicide has a prominent role in the toxic mechanism in living systems. Previous studies have shown that vitamin E can have a protective effect on cells against oxidative damage.
Parastoo Heidari, Farah Farokhi, Gholamreza Najafi, Abbas Sadeghi   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ucOCN Promotes Testosterone Synthesis via the PKA-MAPK/ERK-CREB Signaling Pathway in Porcine Leydig Cells

Cells
Bone health might be closely associated with male fertility, yet the molecular pathways remain poorly characterized. We demonstrate that undercarboxylated osteocalcin (ucOCN), a bone-derived hormone, initiates a signaling cascade that stimulates ...
Guang Yang, Han Liu, Zhibao Yin, Lihua Zhao, Yanglin Chen, Yiqing Li, Linxin Cheng, Junjun Ma, Jinbo Yu, Yu Zhang, Xihe Li, Rongfeng Li   +11 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Pregnancy, Reproductive Factors, and Female Heart Failure Risk and Outcomes

Purpose of review: The purpose of this review is to provide an overview of recent evidence on female-specific risk factors related to reproductive status or pregnancy.
Martínez Sellés Oliveria Soares, Manuel, Martínez-Sellés D Oliveira Soares, Manuel, Moreno Muñoz, Guillermo, Moreno, Guillermo, Vicente Galán, María Jesús, Vicent, Lourdes   +5 more
core   +1 more source

Ethical objections to sex selection for nonmedical reasons [PDF]

, 2008
This paper examines the main ethical argument used to support the use of sex selection for non-medical reasons, namely that sex selection for non-medical reasons should be allowed on the grounds of reproductive autonomy.
Frith, Lucy; id_orcid, Crawshaw, Marilyn, Blyth, Eric, Frith, Lucy   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Infecção por leptospira em bovinos e sua associação com transtornos reprodutivos e condições climáticas Leptospiral infection in bovine and its association with reproductive failure and climatic conditions

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2007
Realizou-se estudo sorológico, por meio do teste de soroaglutinação microscópica, utilizando antígenos vivos, para pesquisa de aglutininas anti-leptospiras em bovinos de leite na Microrregião de Parnaíba, PI, em dois períodos do ano: estações seca e ...
A.L.B.B. Mineiro, E.E.A. Bezerra, S.A. Vasconcellos, F.A.L. Costa, N.A. Macedo   +4 more
doaj   +1 more source