Results 131 to 140 of about 1,229,803 (292)

Offspring BMI and lipid profiles following assisted reproductive technology: a comparative study of underweight and normal-weight mothers

Lipids in Health and Disease
Background The early developmental environment is associated with long-term metabolic health outcomes in children. A large proportion of underweight women tend to become pregnant via assisted reproductive technology (ART).
Zijing Wang, Wenxin Guo, Yujia Ren, Yiyuan Zhang, Jingmei Hu, Yue Liu, Linlin Cui   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Reproductive Health Aid: A Delicate Balancing Act [PDF]

In this contribution the authors show that development assistance targeting reproductive health overwhelmingly concentrates on HIV/AIDS at the expense of family planning elements.
Dalen, H.P. van, Micevska Scharf, M.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

MCM8 interacts with DDX5 to promote R-loop resolution

The EMBO Journal
MCM8 has emerged as a core gene in reproductive aging and is crucial for meiotic homologous recombination repair. It also safeguards genome stability by coordinating the replication stress response during mitosis, but its function in mitotic germ cells ...
Canxin Wen, Lili Cao, Shuhan Wang, Weiwei Xu, Yongze Yu, Simin Zhao, Fan Yang, Zi-Jiang Chen, Shidou Zhao, Yajuan Yang, Yingying Qin   +10 more
doaj   +1 more source

Preconception Care of Women on Prescribed Opioids [PDF]

, 2017
The landmark 2015 report from the Center for Disease Control (CDC) posited that too many women of reproductive age received prescribed opioids. This is significant because fetal exposure to a known teratogen can have catastrophic outcomes.
Norwick, Rebecca-Maria
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Peran Pos Kesehatan Pesantren dalam Meningkatkan Kesehatan Reproduksi Remaja [PDF]

, 2007
In 2006 the Ministry of Health declared to empower the health by Islamic boarding schools or Pos Kesehatan Pesantren (Poskestren). The one of activities poskestren is education about reproductive health for teenagers because almost all members of the ...
Wijayanti, K. (Kharisma)
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

An exploratory study of patients’ experiences with and reasons for using one virtual-only telecontraceptive platform in the United States in 2020–2021

Reproductive Health
Background Telecontraception, whereby one uses a website or mobile application to access contraceptive care, has grown over time, with an increasing number of virtual-only platforms offering this service.
Caila Brander, Kate Grindlay, Daniel Grossman, Carmela Zuniga   +3 more
doaj   +1 more source