Results 111 to 120 of about 1,242,775 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss

BMC Medicine
Background Embryo implantation failure and early pregnancy loss remain significant challenges in assisted reproductive technology (ART). Lipid peroxidation is known to be involved in reproductive physiology.
Zhangwei Jia, Junxiang Ren, Tianxiang Ni, Xinyu Liu, Yuhan Shao, Wei Zhou, Qian Zhang, Chenxi Jin, Jia Yuan, Junhao Yan   +9 more
doaj   +1 more source

Empowering women : the effect of women's decision-making power on reproductive health services uptake -- evidence from Pakistan [PDF]

A large body of research has attempted to explore the links between women's autonomy and their uptake of reproductive health services in the South Asia region, but the evidence so far is inconclusive.
Hou, Xiaohui, Ma, Ning
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Rhapontigenin alleviates cellular senescence and physiological aging by upregulating sirt1 and promoting autophagy

Chinese Medicine
Background Aging is characterized by cellular senescence, inflammation, and physiological decline. Currently available antiaging therapies often have limitations due to their toxicity and off-target effects.
Shuang Liu, Wendi Chen, Guoqiang Xu, Xin Liu, Yuxuan Shi, Guolong Wang, Yunna Ning, Yongzhi Cao, Ming Li, Yueran Zhao   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway

Cell Communication and Signaling
Background Reduced oocyte quality is a key factor in age-related fertility decline, and there are no effective treatments available. The secretome of mesenchymal stem cells (MSC-sec) contains various bioactive factors and has the potential to improve ...
Jing Zhou, Cheng Li, Xin Mi, Jiali Zhou, Caiyi Chen, Jiayi Ren, Ran Liu, Gang Liu, Zi-Jiang Chen, Yingying Qin, Keliang Wu, Shidou Zhao   +11 more
doaj   +1 more source

Ford Foundation Vietnam [PDF]

, 2008
Provides an overview of the foundation's programs and key strategies in Vietnam in development finance; education and scholarship; environment and development; international cooperation; media, arts and culture; and sexuality and reproductive ...

core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Making It Work: Linking Youth Reproductive Health and Livelihoods [PDF]

, 2001
Assesses the challenges and effectiveness of programs that integrate adolescent reproductive health with options that improve economic capabilities, assets, and activities.
Anju Malhotra, Charlotte Johnson-Welch, Guadalupe Duron, Sanyukta Mathur, Simel Esim   +4 more
core