Results 101 to 110 of about 1,242,775 (294)

Feasibility, acceptability and potential sustainability of a ‘diagonal’ approach to health services for female sex workers in Mozambique

BMC Health Services Research, 2018
Background Female sex workers (FSWs) in many settings have restricted access to sexual and reproductive health (SRH) services. We therefore conducted an implementation study to test a ‘diagonal’ intervention which combined strengthening of FSW-targeted ...
Yves Lafort, Malica Sofia Ismael de Melo, Faustino Lessitala, Sally Griffin, Matthew Chersich, Wim Delva   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Insufficient NNMT promotes autophagy and disrupts progesterone signaling in endometrial stromal cells in recurrent implantation failure by modulating the H3K9me3-ALDH1A3 pathway

Cell Death Discovery
Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear.
Yifei Song, Shaotong Zhao, Xianping Hou, Jiayuan Chen, Qian Zhang, Shizhen Su, Junhao Yan, Tianxiang Ni   +7 more
doaj   +1 more source

Adolescent childbearing experiences in Kenya: geographical and socioeconomic determinants [PDF]

Sub-Saharan Africa has one of the highest level of teenage pregnancies in the world. Some studies on this topic highlight the presence of unmet reproductive health needs of adolescent in different regions.
Angelina Mazzocchetti, Aurora Angeli, Carla Pezzulo, Rosella Rettaroli   +3 more
core   +1 more source

Why Family Planning and Reproductive Health are Critical to the Well-Being of Youth [PDF]

, 2009
An unprecedented number of young people are entering their reproductive years, most of whom live in the developing world. U.S. policy makers should assist in effortS to ensure that youth worldwide are able to make informed decisions about their sexuality

core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Spiritual Well-Being, Self-Esteem and Intimacy Among Couples Using Natural Family Planning [PDF]

, 1994
Making decisions about achieving and avoiding pregnancy and the methods used to attain those ends are some of the most central decisions during a couple\u27s reproductive life.
Fehring, Richard J., Lawrence, Donna M.
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos

Nature Communications
With the advent and development of assisted reproductive technology (ART), more and more people affected by infertility have been able to obtain offspring successfully. Nevertheless, various adverse outcomes have been found to be associated with ART, and
Chuanxin Zhang, Hao Tian, Xiaoyu Yin, Xueqi Dong, Ning Wang, Yiwen Zhang, Jiawei Wang, Jinzhu Song, Cheng Li, Zi-Jiang Chen, Boyang Liu, Keliang Wu   +11 more
doaj   +1 more source