Results 81 to 90 of about 597,252 (225)

Fruitful Futures for Reproductive Health [PDF]

Trends in Molecular Medicine, 2021
Claudia G, Willmes, Matthew, Beymer
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos

Nature Communications
With the advent and development of assisted reproductive technology (ART), more and more people affected by infertility have been able to obtain offspring successfully. Nevertheless, various adverse outcomes have been found to be associated with ART, and
Chuanxin Zhang, Hao Tian, Xiaoyu Yin, Xueqi Dong, Ning Wang, Yiwen Zhang, Jiawei Wang, Jinzhu Song, Cheng Li, Zi-Jiang Chen, Boyang Liu, Keliang Wu   +11 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Social isolation and loneliness associate with early menopause and mortality in women: a UK Biobank cohort study

BMC Medicine
Background Reproductive aging is an emerging public health priority amid demographic shifts. Early menopause (EM), indicative of accelerated reproductive aging, is associated with an elevated risk of premature mortality.
Yuteng Wang, Yu Qi, Zifeng Cao, Keyan Xu, Ruoliu Xia, Shigang Zhao, Linlin Cui, Daimin Wei, Han Zhao, Shuyan Tang, Yingying Qin, Ting Guo   +11 more
doaj   +1 more source

Gender and Reproductive Health [PDF]

, 2001
Smelser, Neil J. [Hrsg.], Baltes, Paul B. [Hrsg.]   +1 more
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway

Cell Communication and Signaling
Background Reduced oocyte quality is a key factor in age-related fertility decline, and there are no effective treatments available. The secretome of mesenchymal stem cells (MSC-sec) contains various bioactive factors and has the potential to improve ...
Jing Zhou, Cheng Li, Xin Mi, Jiali Zhou, Caiyi Chen, Jiayi Ren, Ran Liu, Gang Liu, Zi-Jiang Chen, Yingying Qin, Keliang Wu, Shidou Zhao   +11 more
doaj   +1 more source