Results 41 to 50 of about 1,737,675 (280)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Pre-birth child protection and the reproductive rights of fathers [PDF]
, 2023 INTRODUCTION: Whilst acknowledging that child-welfare-involved pregnant women occupy a uniquely precarious position in terms of their human dignity and rights, this paper focuses on the vulnerabilities of fathers of children subject to child protection ...
Critchley, Ariane
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
What have we learned about reproductive justice from a philosophical point of view?
Open Gender JournalIn this short essay, the conference on "Reproductive justice in the context of queer and trans Reproduction with assisted reproductive technologies," which took place in Graz in February 2024, and the presentations associated with it, are discussed from
Mario Kropf
doaj +1 more source
BMC Women's Health, 2021 Background Women may need or seek male partner approval to safely and consistently use oral antiretroviral pre-exposure prophylaxis (PrEP) or vaginal microbicides.
Ellen K. Wilson +10 more
doaj +1 more source
At the intersection of climate justice and reproductive justice
WIREs Climate Change, 2023 Abstract Climate justice and reproductive justice are distinct scholarly and activist frameworks that have received significant attention in recent years—particularly with respect to how they might be linked together. In this overview, I survey the main lenses through which various actors have linked climate justice and reproductive ...
openaire +1 more source
Reproducing Rights: The Intersection of Reproductive Justice and Human Rights
, 2017 This Article argues that reproductive justice writings, by relying on human rights arguments, may perpetuate a limited vision for global justice—one that contradicts the movement’s core commitments and detracts from the change that the movement’s ...
Rebouché, Rachel
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
A Political Space that Wasn’t There Before
RSA JournalThis interview with Loretta Ross, a foundational figure in the Black feminist movement and a co-creator of the Reproductive Justice framework, provides a comprehensive overview of her life’s work and political perspectives.
Bruno Walter Renato Toscano
doaj +1 more source