Results 181 to 190 of about 239,150 (314)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Effects of combining Beauveria bassiana and Nosema pyrausta on the mortality of Ostrinia nubilalis

Open Life Sciences, 2010
Abdel Rahman Khaled, Barta Marek, Cagáň Ľudovít   +2 more
doaj   +1 more source

Quercetin upregulates steroid hormone biosynthesis to enhance reproductive performance in roosters. [PDF]

Poult Sci
Zhang L, Chen Z, Yang M, Sun H, Lan M, Yu L, Tan H, Xu H, Liu X, Ran M, Lu Y.   +10 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effects of Heat Stress on Semen Quality and Reproductive Performance of Crossbred Boars with Different Maternal Origins. [PDF]

Animals (Basel)
Lee HL, Kuo TY, Peng LL, Hsu CB, Lin CY, Chang SC, Lee YH, Lai IL, Chang HL, Shen PC.   +9 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Evaluating light spectrum and intensity for female turkey breeder reproductive performance. [PDF]

Poult Sci
Ziezold CJ, Bédécarrats GY.
europepmc   +1 more source

Effects of silymarin supplementation during late gestation on reproductive performance, haematological parameters, antioxidant status, and gut microbiota in sows

This study aimed to evaluate the effects of silymarin supplementation during late gestation on reproductive performance, haematological parameters, antioxidant capacity, and gut microbiota composition in sows.
Junbo Li, Chunxue Liu, Guanglei Cong, Ifen Hung, Shuangshuang Xia   +4 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A Comparison of Implementation of Synchronization, Artificial Insemination and Sex-Skewed Semen on Reproductive Performance and Calving Distribution in Beef Herds. [PDF]

Animals (Basel)
Menegatti Zoca S, Perry GA, Diersen MA, Rusche WC, Northrop-Albrecht EJ, Rich JJJ, Epperson KM, Perkins-Oines SD, Walker JA.   +8 more
europepmc   +1 more source