Results 201 to 210 of about 210,950 (263)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Early Detection and Long-Term Monitoring as a Strategy for African Swine Fever Outbreak Control and a Comparative Study on the Reproductive Performance of Convalescent and Naïve Sows in a Commercial Farm in Thailand. [PDF]

Animals (Basel)
Wathirunwong T, Jiwakanon J, Depner K, Porntrakulpipat S.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Water hyacinth: A promising functional feed ingredient to optimize reproductive performance in Garut rams. [PDF]

Open Vet J
Nurlatifah A, Prihantoko KD, Menassol JB, Herdis H, Diansyah AM, Khan FA, Maidin MS.   +6 more
europepmc   +1 more source

Correction: Early weaning in pigeons (Columba Livia domestica): effects on squabs performance and reproductive performance of parents. [PDF]

BMC Vet Res
Mohamed OA, Khattab IM, Elsagheer MA.
europepmc   +1 more source

Effects of birth season and reproductive performance in Romanov-derived F1 ewes in terminal crossbreeding. [PDF]

Open Vet J
Aslan FA, Emsen E.
europepmc   +1 more source

Influence of short-term dexamethasone-induced stress on behavioral, physiological and reproductive performance of growing rabbit bucks. [PDF]

BMC Vet Res
El-Azzazi FE, Elnesr SS, Ibrahim IMM, Ali AA.   +3 more
europepmc   +1 more source

Impact of daytime and supplemental feeder light spectrum on female broiler breeder growth and reproductive performance. [PDF]

Poult Sci
Takeshima K, Zuidhof MJ, Hanlon C, Bédécarrats GY.   +3 more
europepmc   +1 more source

Does Dietary Vitamin E Improve Efficiency of Selenium Nanoparticles on Reproductive Performance in Marine Fish? Using Arabian Yellowfin Seabream (<i>Acanthopagrus arabicus</i>) Female Brooder as an Experimental Model. [PDF]

Aquac Nutr
Saffari S, Mozanzadeh MT, Khademzadeh O.
europepmc   +1 more source

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Reproductive Performance after Ectopic Pregnancy

Seminars in Reproductive Medicine, 2007
Reproductive performance may be an important variable in treatment selection for unruptured ectopic pregnancy. The impact of treatment choice on reproductive performance is not known. We searched the literature and then tabulated published case reports on laparoscopic salpingostomy, multiple-dose methotrexate, single-dose methotrexate, and expectant ...
John E Buster
exaly   +3 more sources