Results 41 to 50 of about 613,910 (308)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Use Opportunities of Hydrated Fullerene Nanoparticles for Hypothermic Storage of Industrial Oysters

Materials Proceedings, 2023
Hydrated fullerene (C60FWS) as an aqueous colloidal solution exhibits a wide range of biological activity at low concentrations. The purpose of this work was to study the effect of hydrated fullerene nanoparticles on the safety of Pacific oysters ...
Oksana Falko, Viktor Chizhevskiy, Olexandr Ponomarenko, Victoria Evlash, Inna Piliugina, Sergey Gubsky   +5 more
doaj   +1 more source

“Boys Remain Prestigious, Girls Become Prostitutes”: Socio-Cultural Context of Relationships and Sex among Young People in Nepal [PDF]

, 2010
One of the key characteristics of many developing countries compared to more developed countries is that their population is relatively young, and a proportion of those young people are becoming sexually active each year.
Regmi, Pramod, Simkhada, Padam, van Teijlingen, Edwin   +2 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Avaliação do controle de leptospirose por vacinação em bovinos de propriedade leiteira no estado do Piauí

Arquivos do Instituto Biológico
Neste estudo foram colhidos soros de 255 vacas e 2 touros no período de 2004 a 2009, em intervalos de seis meses, em uma fazenda de gado leiteiro no município de Buriti dos Lopes, Piauí. Pela técnica de soroaglutinação microscópica (SAM), os sorovares de
Ana Lys Bezerra Barradas Mineiro, Rômulo José Vieira, Eduardo Esmeraldo Augusto Beserra, Layana Mauriz Leal, Francisco Assis Leite Sousa, Ângela Piauilino Campos, Élvio Carlos Moreira, Francisco Assis Lima Costa   +7 more
doaj   +1 more source

Education of Adolescents on Reproductive Health- Which way to Go

Journal of Nepal Medical Association, 2010
INTRODUCTION: The study was done to assess the educational needs of the adolescent girl students regarding their reproductive health. METHODS: The data were collected by administering an open-ended self-administered questionnaire to the ...
S Roy
doaj   +1 more source

ESHRE task force on ethics and law 15: Cross-border reproductive care [PDF]

, 2008
This paper analyses the ethical aspects of cross-border reproductive care. Ethical questions are raised by some of the main reasons of cross-border travelling, i.e. law evasion and unequal access to treatment.
Cohen, J., de Wert, G., Devroey, P., Pennings, Guido, Shenfield, F., Tarlatzis, B.   +5 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Major reproductive health problems of indigenous Borena cows in Ethiopia

Journal of Advanced Veterinary and Animal Research, 2014
The study was conducted to identify the major reproductive health problems and its associated risk factors in indigenous Borena breed cows in Borena zone in Southern Ethiopia between September 2013 and February 2014.
Ararsa Duguma Benti, Wubishet Zewdie
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source