Results 51 to 60 of about 613,910 (308)

Effects of Decamethylcyclopentasiloxane on Reproductive Systems in Female Rats

Toxics, 2023
The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by ...
Jimin Lee, Kangmin Kim, Seon-Mi Park, Jin-Sook Kwon, Eui-Bae Jeung   +4 more
doaj   +1 more source

Silent Spring - the lost call [PDF]

, 2008
The "silence" in Rachel Carson's Silent Spring1 alludes to the demise of bird populations through reproductive problems and death resulting from exposure to the pesticides of that time, many of which are endocrine active.
Mary Ann Ottinger, Michael J. Quinn
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Seroprevalence and risk factors for Neospora caninum in goats in Santa Catarina state, Brazil

Revista Brasileira de Parasitologia Veterinária
Neosporosis is an infectious disease caused by the parasite Neospora caninum. Knowledge regarding neosporosis in goats is still quite limited, especially in the state of Santa Catarina (SC), southern Brazil.
Josué Pires Topazio, Augusto Weber, Giovana Camillo, Fernanda Flores Vogel, Gustavo Machado, André Ribeiro, Anderson Barbosa Moura, Leandro Sâmia Lopes, Alexandre Alberto Tonin, Natan Marcos Soldá, Patrícia Bräunig, Aleksandro Schafer da Silva   +11 more
doaj   +1 more source

Neospora caninum infection and reproductive disorders in Creole goats from southern Peru: A Bayesian mediation analysis across agroecological zones [PDF]

Veterinary World
Background and Aim: Neosporosis, caused by Neospora caninum, is an important infectious cause of reproductive failure in ruminants, yet its epidemiological role in goats from hyper-arid coastal ecosystems remains poorly understood.
Jhony Soca, Marisela Trillo-Salvador, Justo Valdivia-Zevallos, Juan Canchino-Gutierrez, Emmanuel Alexander Sessarego, Edwin Mendoza-Alacute, Victor Temoche-Socola, Juancarlos Cruz-Luis, Danny Julio Cruz   +8 more
doaj   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Reproductive Health Problems in Adolescents in Banten Province

Global Medical & Health Communication, 2019
Teenagers are the next generation that needs to be the center of attention. Physical and mental development in adolescents occurs rapidly. The process of changing times with free association arises causing debate about their reproductive health.
Ismiyati Ismiyati, Udin Sabarudin, Tuti Wahmurti A. Sapiie, Farid Husin, Susi Susanah, Deni Kurniadi Sunjaya   +5 more
doaj   +1 more source