Results 131 to 140 of about 105,952 (293)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

From Choice to Justice: Disrupting the Binary Political Logics of Assisted Reproduction [PDF]

Health and Human Rights
Reproductive rights and reproductive justice paradigms have long been viewed as incompatible, largely because of their divergent orientations to the notion of choice.
Leifa Mayers
doaj  

Èquipe, community, traditional values, and reproductive rights. [PDF]

Front Sociol, 2022
Corvino I, D'Andrea F.
europepmc   +1 more source

Reproductive Rights

, 2015
Violencia basada en género. Evaluación de la integridad sexual. Derechos sexuales y reproductivos en el Perú. Avances en la iniciativa Figo: Prevención del aborto inseguro.
Toro Merlo, Judith, Mallaupoma Povez, Sonia, Távara Orozco, Luis   +2 more
openaire   +1 more source

Capabilities and structural vulnerabilities of women's reproductive rights : the complex case of south America.

, 2014
IN terms of reproductive rights and capabilities to enforce those rights , the south american continent offers many different levels of regulations and women involvment .
Botbol-Baum, Mylene, forum franco-latino americano de bioetica , Santiago, reproductive rights in south america   +1 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

InfoAdoMali – Sexual and reproductive health rights and young people: A case study from Mali

, 2014
In most developing countries, the subject of sexuality and reproductive health of young people is often seen as taboo due to local culture and religion.
Ofomata, Uju, Cisse, Sitan, Toure, Aissa
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

AWARENESS ABOUT REPRODUCTIVE HEALTH AND RIGHTS AMONG STUDENTS OF A PUBLIC UNIVERSITY IN KARACHI, PAKISTAN: A CROSS SECTIONAL STUDY

Journal of the Dow University of Health Sciences, 2007
Objective: To determine the knowledge, attitude and practices of Karachi University students about reproductive health and rights. Design: Cross sectional study Methods: A survey was conducted from February to May 2005 to determine the ...
Naheed Nabi, Waris Qidwai, Farhat Batool, Syed Iqbal Azam   +3 more
doaj