Results 181 to 190 of about 1,774,490 (339)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A sexual and reproductive health and rights journey: from Cairo to the present

Sexual and Reproductive Health Matters, 2019
Rebecca Brown, Eszter Kismödi, Rajat Khosla, S. Malla, Lucy Asuagbor, Ximena Andión-Ibanez, Sofia Gruskin   +6 more
doaj   +1 more source

FemTech: empowering reproductive rights or FEM-TRAP for surveillance? [PDF]

Med Law Rev
Hofmann D.
europepmc   +1 more source

Preserving the Reproductive Rights of Girls and Women in the Era of COVID-19: The Need for a Least Restrictive Solution. [PDF]

Am J Bioeth, 2020
Ott MA, Bernard C.
europepmc   +1 more source

Intersectionality and the Struggle for Sexual and Reproductive Health and Rights: An Analysis of UN Discursive Patterns [PDF]

, 2012
Amie Ritchie
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Decrease in reproductive desires among non-parent heterosexual women during the COVID-19 pandemic in Poland: the role of epidemiological stress, socioeconomic status, and reproductive rights. [PDF]

Front Public Health
Marcinkowska UM, Kasparek KK, Zabdyr-Jamróz M, Kozłowska M, Nenko I.   +4 more
europepmc   +1 more source

Universal health coverage: another political space in which to expand the elimination of sexual and reproductive health and reproductive rights. [PDF]

Sex Reprod Health Matters, 2020
Gilby L, Koivusalo M.
europepmc   +1 more source

About goats, girls, boys and the bees : promoting adolescents’ sexual and reproductive health and rights in Uganda, Indonesia and Thailand; an Intervention Mapping approach [PDF]

, 2013
Joanne N. Leerlooijer
openalex   +1 more source