Results 41 to 50 of about 159,419 (242)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Implications of inflorescence clustering for the visitation rate by hummingbirds and fruit production by Heliconia bihai (L.) L. (Heliconiaceae)

Biotemas, 2015
Plant spatial distribution can influence the activity of floral visitors. Flower clustering in patches may be more attractive to visitors and it supposedly influences the fruit production.
Caio César Corrêa Missagia , Fábio de Castro Verçoza   +1 more
doaj  

Sense and Nonsense in Metabolic Control of Reproduction

Frontiers in Endocrinology, 2012
An exciting synergistic interaction occurs among researchers working at the interface of reproductive biology and energy homeostasis. Reproductive biologists benefit from the theories, experimental designs, and methodologies used by experts on energy ...
Jill eSchneider, Candice M. Klingerman, Amir A. Abdulhay   +2 more
doaj   +1 more source

Extrinsic and intrinsic factors drive the timing of gestation and reproductive success of Scandinavian brown bears

Frontiers in Ecology and Evolution, 2022
IntroductionClimate change is altering the reproductive phenology of many organisms, but the factors that influence the timing of gestation in ursids are still poorly understood.
Lucie Lemière, Alexandra Thiel, Boris Fuchs, Emmanuelle Gilot-Fromont, Anne G. Hertel, Andrea Friebe, Andrea Friebe, Jonas Kindberg, Jonas Kindberg, Ole-Gunnar Støen, Ole-Gunnar Støen, Jon M. Arnemo, Jon M. Arnemo, Alina L. Evans   +13 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Maternal health status correlates with nest success of leatherback sea turtles (Dermochelys coriacea) from Florida. [PDF]

PLoS ONE, 2012
Of the seven sea turtle species, the critically endangered leatherback sea turtle (Dermochelys coriacea) exhibits the lowest and most variable nest success (i.e., hatching success and emergence success) for reasons that remain largely unknown.
Justin R Perrault, Debra L Miller, Erica Eads, Chris Johnson, Anita Merrill, Larry J Thompson, Jeanette Wyneken   +6 more
doaj   +1 more source

Could the reproductive system explain the stability and long-term persistence in a natural hybrid zone of Petunia (Solanaceae)?

Acta Botânica Brasílica, 2022
The long-term success of populations is dependent on individual reproductive success, and in general, increased population size and genetic diversity contribute to population maintenance, reducing the risk of local extinction. Interspecific hybridization
Marcelo C. Teixeira, Caroline Turchetto, Carolina K. Schnitzler, Sidia M. Callegari-Jacques, Loreta B. Freitas   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source